Evidence map›Paper›PMID 37580799›Full record

ArticleAging2023

Associations between klotho and telomere biology in high stress caregivers.

Ryan L Brown, Elissa E Epel, Jue Lin, Dena B Dubal, Aric A Prather

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ryan L BrownDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA 94107, USA.
Elissa E EpelDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA 94107, USA.
Jue LinDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94107, USA.
Dena B DubalDepartment of Neurology and Weill Institute of Neurosciences, University of California, San Francisco, CA 94107, USA.
Aric A PratherDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA 94107, USA.
University of California, San Francisco · US

Funding

Psychology & Medicine: Translational Research on Stress, Behavior and DiseaseT32MH019391 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ADLER, NANCY E, EPEL, ELISSA S. · 1991 to 2022
$4.4M
Chronic and Acute Psychosocial Stress and Impaired Cell AgingR01AG030424 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EPEL, ELISSA S. · 2010 to 2014
$3.5M
Sleep as a novel pathway linking chronic psychological stress and inflammationK08HL112961 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRATHER, ARIC ANDREW · 2012 to 2016
$723k
Collagen VI: Novel Mechanisms and Functions in Alzheimer's DiseaseK08AG034531 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUBAL, DENA BOU · 2009 to 2013
$540k
Stress-induced poor sleep: Sex differences, vulnerability & resilience factorsR21HL117727 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EPEL, ELISSA S. · 2012 to 2013
$418k
Chronic and Acute Psychosocial Stress and Impaired Cell AgingR56AG030424 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EPEL, ELISSA S. · 2008 to 2009
$260k
NHLBI NIH HHS K08 HL112961NHLBI NIH HHS R21 HL117727NIA NIH HHS K08 AG034531NIA NIH HHS R01 AG030424NIA NIH HHS R56 AG030424NIMH NIH HHS T32 MH019391
6 · The paper itself

Abstract

Aging biomarkers may be related to each other through direct co-regulation and/or through being regulated by common processes associated with chronological aging or stress. Klotho is an aging regulator that acts as a circulating hormone with critical involvement in regulating insulin signaling, phosphate homeostasis, oxidative stress, and age-related inflammatory functioning. Both klotho and telomere length are biomarkers of biological aging and decrease with age; however, the relationship between them is not well understood. Here we test the association between klotho levels and the telomere length of specific sorted immune cells among a healthy sample of mothers caregiving for a child with autism spectrum disorder (ASD; i.e., experiencing higher caregiving stress) or a child without ASD, covarying age and body mass index, in order to understand if high stress associated with caregiving for a child with an ASD may be involved in any association between these aging biomarkers. In 178 caregiving women (

Indexed as

Autism Spectrum DisorderCaregiversAgingBiologyBiomarkersFemaleHumansTelomereTelomere ShorteningBiomarkersaging biologyklothostresstelomerasetelomeres

Identifiers

PMID37580799
PMCPMC10457041
OpenAlexW4385800414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.