Evidence map›Paper›PMID 37580793›Full record

ArticleBreast cancer research : BCR2023

Circulating 27-hydroxycholesterol, lipids, and steroid hormones in breast cancer risk: a nested case-control study of the Multiethnic Cohort Study.

Mindy C DeRouen, Juan Yang, Yuqing Li, Adrian A Franke, Anne N Tome, Kami K White, Brenda Y Hernandez, Yurii Shvetsov, Veronica Setiawan, Anna H Wu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research : BCR, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Mindy C DeRouenDepartment of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, 550 16th Street, San Francisco, CA, 94538, USA. mindy.hebert-derouen@ucsf.edu.
Juan YangDepartment of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, 550 16th Street, San Francisco, CA, 94538, USA.
Yuqing LiDepartment of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, 550 16th Street, San Francisco, CA, 94538, USA.
Adrian A FrankeCancer Biology Program, University of Hawai'i Cancer Center, Honolulu, HI, USA.
Anne N TomePopulation Sciences of the Pacific Program, University of Hawai'i Cancer Center, Honolulu, HI, USA.
Kami K WhitePopulation Sciences of the Pacific Program, University of Hawai'i Cancer Center, Honolulu, HI, USA.
Brenda Y HernandezPopulation Sciences of the Pacific Program, University of Hawai'i Cancer Center, Honolulu, HI, USA.
Yurii ShvetsovPopulation Sciences of the Pacific Program, University of Hawai'i Cancer Center, Honolulu, HI, USA.
Veronica SetiawanDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Anna H WuDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lynne R WilkensPopulation Sciences of the Pacific Program, University of Hawai'i Cancer Center, Honolulu, HI, USA.
Loïc Le MarchandPopulation Sciences of the Pacific Program, University of Hawai'i Cancer Center, Honolulu, HI, USA.
Lenora W M Loo *Cancer Biology Program, University of Hawai'i Cancer Center, Honolulu, HI, USA.
Iona Cheng *Department of Epidemiology and Biostatistics, School of Medicine, University of California San Francisco, 550 16th Street, San Francisco, CA, 94538, USA. iona.cheng@ucsf.edu.
University of California, San Francisco · USUniversity of Hawaiʻi at Mānoa · USUniversity of Hawaii System · USUniversity of Southern California · USCancer Center of Hawaii · USUniversity of Hawaii Cancer Center

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
University of Guam/Cancer Research Center of Hawaii Partnership (2 of 2)U54CA143728 · NCI · UNIVERSITY OF GUAM · PI RACHAEL T LEON GUERRERO · 2009 to 2026
$20.1M
University of Guam/Cancer Research Center of Hawaii Partnership (1 of 2)U54CA143727 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Brenda Yukari Hernandez, RACHAEL T LEON GUERRERO · 2009 to 2026
$19.1M
The Role of 27-hydroxycholesterol in Breast Cancer: A Population-Based Multiethnic StudyR01CA229815 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI CHENG, IONA C, LOO, LENORA WM · 2019 to 2023
$3.5M
NCI NIH HHS HHSN261201300009INCI NIH HHS HHSN261201800009INCI NIH HHS HHSN261201800015INCI NIH HHS HHSN261201800032INCI NIH HHS P30 CA071789NCI NIH HHS R01 CA229815NCI NIH HHS U01 CA164973NCI NIH HHS U54 CA143727NCI NIH HHS U54 CA143728
6 · The paper itself

Abstract

backgroundLaboratory studies have indicated that a cholesterol metabolite and selective estrogen receptor modulator, 27-hydroxycholesterol (27HC), may be important in breast cancer etiology and explain associations between obesity and postmenopausal breast cancer risk. Epidemiologic evidence for 27HC in breast cancer risk is limited, particularly in multiethnic populations.

methodsIn a nested case-control study of 1470 breast cancer cases and 1470 matched controls within the Multiethnic Cohort Study, we examined associations of pre-diagnostic circulating 27HC with breast cancer risk among African American, Japanese American, Native Hawaiian, Latino, and non-Latino White postmenopausal females. We used multivariable logistic regression adjusted for age, education, parity, body mass index, and smoking status. Stratified analyses were conducted across racial and ethnic groups, hormone receptor (HR) status, and use of lipid-lowering drugs. We assessed interactions of 27HC with steroid hormones.

results27HC levels were inversely related to breast cancer risk (odds ratio [OR] 0.80; 95% confidence interval [CI] 0.58, 1.12), but the association was not statistically significant in the full model. Directions of associations differed by racial and ethnic group. Results suggested an inverse association with HR-negative breast cancer (OR 0.46; 95% CI 0.20, 1.06). 27HC interacted with testosterone, but not estrone, on risk of breast cancer; 27HC was only inversely associated with risk among those with the highest levels of testosterone (OR 0.46; 95% CI 0.24, 0.86).

conclusionThis is the first US study to examine circulating 27HC and breast cancer risk and reports a weak inverse association that varies across racial and ethnic groups and testosterone level.

Indexed as

Breast NeoplasmsCase-Control StudiesCohort StudiesFemaleHumansHydroxycholesterolsRisk FactorsTestosterone27-hydroxycholesterolHydroxycholesterolsTestosterone27-HydroxycholesterolBreast cancer riskLipidsRace and ethnicitySteroid hormones

Identifiers

PMID37580793
PMCPMC10424359
OpenAlexW4385809201

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.