Evidence map›Paper›PMID 37580739›Full record

Trial reportHealth and quality of life outcomes2023

Distorted thoughts as a mediator of depressive symptoms in patients with major depressive disorder: a longitudinal study.

Adriana Munhoz Carneiro, Danilo Assis Pereira, Fernando Fernandes, Makilim Nunes Baptista, André Russowsky Brunoni, Ricardo Alberto Moreno

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Health and quality of life outcomes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02268487 (THE AIUNI - Integral Assessment in Unipolar Depression), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02268487 phase4unknown statusnot on this map

THE AIUNI - Integral Assessment in Unipolar Depression

TypeinterventionalSponsorUniversity of Sao PauloRan2014 to 2017Enrolled100ConditionsMajor Depressive DisorderArmsSertraline
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Adriana Munhoz CarneiroMood Disorders Unit, Faculty of Medicine FMUSP, University of Sao Paulo, BR Ovideo Pires de Campos St., São Paulo, SP, 785 05403-010, Brazil. adrianacarneiro01@gmail.com.
Danilo Assis PereiraIndependent Consultant, Brasilia, Brazil.
Fernando FernandesMood Disorders Unit, Faculty of Medicine FMUSP, University of Sao Paulo, BR Ovideo Pires de Campos St., São Paulo, SP, 785 05403-010, Brazil.
Makilim Nunes BaptistaLaboratory of Psychometric Evaluation in Mental Health -LAPSAM III - São Francisco University, Campinas, Brazil.
André Russowsky BrunoniDepartment of Internal Medicine, Faculty of Medicine FMUSP, University of Sao Paulo, São Paulo, SP, Brazil.
Ricardo Alberto MorenoMood Disorders Unit, Faculty of Medicine FMUSP, University of Sao Paulo, BR Ovideo Pires de Campos St., São Paulo, SP, 785 05403-010, Brazil.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP 2015/22564-9, 03.01.2016-10.31.2018
6 · The paper itself

Abstract

backgroundDistorted thoughts are common in Major Depressive Disorder (MDD), and can impact patients' perceptions of depression severity, and predict chronicity and treatment response. This study aimed to investigate whether distorted thoughts mediate depressive symptoms in MDD over a 6-month period.

methodThese are secondary results from a study that followed 119 patients diagnosed with moderate to severe MDD for 6 months. Diagnoses were confirmed by the Structured Interview for DSM-IV (SCID-CV). The analysis was composed of results from the Hamilton Depression Rating Scale (HAMD-17), the Montgomery-Asberg Depression Rating Scale (MADRS), the second edition of the Beck Depression Inventory (BDI-II), and the Depression Thoughts Scale (DTS) collected at weeks 1, 8, 12 and 24.

resultsResults showed that the DTS mediated the relationship between depressive symptoms experienced approximately 3 months after starting antidepressant treatment.

conclusionCognitive distortions were linked as a mediator to depressive symptoms, highlighting the importance of early psychological interventions in patients with MDD who exhibit these distortions.

trial registrationNCT02268487.

Indexed as

Major Depressive DisorderAntidepressive AgentsDepressionHumansLongitudinal StudiesPsychiatric Status Rating ScalesQuality of LifeAntidepressive AgentsCognitive distortionsDepressionDepressive disorderDysfunctional thinkingMediationThinking

Identifiers

PMID37580739
PMCPMC10424419

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.