Evidence map›Paper›PMID 37580614›Full record

ArticleEuropean radiology experimental2023

In vivo tracking of adenoviral-transduced iron oxide-labeled bone marrow-derived dendritic cells using magnetic particle imaging.

Corby Fink, Julia J Gevaert, John W Barrett, Jimmy D Dikeakos, Paula J Foster, Gregory A Dekaban

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European radiology experimental, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. On the partial volume effect in magnetic particle imaging.Physics in medicine and biology · 2025
    Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Corby FinkBiotherapeutics Research Laboratory, Robarts Research Institute, London, ON, Canada.
Julia J GevaertCellular and Molecular Imaging Group, Robarts Research Institute, London, ON, Canada.
John W BarrettDepartment of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, ON, Canada.
Jimmy D DikeakosDepartment of Microbiology and Immunology, University of Western Ontario, London, ON, Canada.
Paula J FosterCellular and Molecular Imaging Group, Robarts Research Institute, London, ON, Canada.
Gregory A DekabanBiotherapeutics Research Laboratory, Robarts Research Institute, London, ON, Canada. dekaban@uwo.ca.ORCID 0000-0002-3087-4660
Western University · CA

Funding

CIHR
6 · The paper itself

Abstract

backgroundDespite widespread study of dendritic cell (DC)-based cancer immunotherapies, the in vivo postinjection fate of DC remains largely unknown. Due in part to a lack of quantifiable imaging modalities, this is troubling as the amount of DC migration to secondary lymphoid organs correlates with therapeutic efficacy. Magnetic particle imaging (MPI) has emerged as a suitable modality to quantify in vivo migration of superparamagnetic iron oxide (SPIO)-labeled DC. Herein, we describe a popliteal lymph node (pLN)-focused MPI scan to quantify DC in vivo migration accurately and consistently.

methodsAdenovirus (Ad)-transduced SPIO

resultsNo significant differences in viability, phenotype and in vivo pLN migration were noted for Ad SPIO

conclusionWe overcame a reported limitation of MPI by using a pLN-focused MPI scan to quantify pLN-migrated Ad SPIO RELEVANCE STATEMENT: Tracking the in vivo fate of DC using noninvasive quantifiable magnetic particle imaging can potentially serve as a surrogate marker of therapeutic effectiveness. KEY POINTS: • Adenoviral-transduced and iron oxide-labeled dendritic cells are in vivo migration competent. • Magnetic particle imaging is a suitable modality to quantify in vivo dendritic cell migration. • Magnetic particle imaging focused field of view overcomes dynamic range limitation.

Indexed as

Bone MarrowMagnetic Resonance ImagingAdenoviridaeAnimalsCell MovementDendritic CellsFerric CompoundsMagnetic PhenomenaMiceMice, Inbred C57BLFerric Compoundsferric oxideAdenoviridaeCell trackingImmunotherapyMagnetic iron oxide nanoparticlesMice (inbred C57BL/6)

Identifiers

PMID37580614
PMCPMC10425309
OpenAlexW4385803438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.