ArticleNature immunology2023
Single-cell multiomic analysis of thymocyte development reveals drivers of CD4
Open access · hybridAbstract read
In one paragraph
Article in Nature immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 53 citations in OpenAlex.
- Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance.Immunology · 2026Review
- Ly6d expression delineates two putative postnatal thymus epithelial progenitor cells that are differentially affected by aging.Science advances · 2026Article
- GPR15-GPR15L axis controls colon natural TCRαβ cells residency and enteroendocrine cell homeostasis to calibrate metabolism.Mucosal immunology · 2026Article
- Rag1-based time-stamp tracing of T-cell developmental origins.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- PD-1 regulates latent effector differentiation of thymic cytotoxic CD8Nature communications · 2026Article
- Unraveling CD8 lineage decisions reveals that functionally distinct CD8Nature immunology · 2026Article
- UBL3 Participates in the Early Stages of CD83-Dependent CD4European journal of immunology · 2026Article
- HIDF: Integrating Tree-Structured scRNA-seq Heterogeneity for Hierarchical Deconvolution of Spatial Transcriptomics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Adaptive-like CAR-iPSC-CD4⁺ T cells outperform CD8⁺ counterparts in sustained ALL control.Inflammation and regeneration · 2026Article
- Mechanisms of T cell activation: Integrating signaling pathways, experimental models, and therapeutic implications.EXCLI journal · 2026Review
- Single-cell transcriptome delineating asymmetric dynamics of CD4Frontiers in immunology · 2026Article
- Aire-dependent interferon signalling shapes thymocyte maturation and central tolerance in mice.Communications biology · 2025Article
- Dynamic Synthesis of Multi-Modal Representations for CITE-seq Data Integration and Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Preselection CD4bioRxiv : the preprint server for biology · 2025Article
- Double-positive T cells form heterotypic clusters with circulating tumor cells to foster cancer metastasis.The Journal of clinical investigation · 2025Article
- Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025Review
- Scvi-hub: an actionable repository for model-driven single-cell analysis.Nature methods · 2025Article
- Article
- A Dapl1Science advances · 2025Article
- Developmental features and unique characteristics of peptide-specific PLZFNature communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 2 countries.
Zoë Steier *University of California, Berkeley, Department of Bioengineering, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-1488-7995
Dominik A Aylard *University of California, Berkeley, Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Berkeley, CA, USA.
Laura L McIntyreUniversity of California, Berkeley, Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Berkeley, CA, USA.
Isabel BaldwinUniversity of California, Berkeley, Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Berkeley, CA, USA.ORCID http://orcid.org/0009-0000-4797-7052
Esther Jeong Yoon KimUniversity of California, Berkeley, Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-4436-3826
Lydia K LutesUniversity of California, Berkeley, Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Berkeley, CA, USA.
Can ErgenUniversity of California, Berkeley, Center for Computational Biology, Berkeley, CA, USA.
Tse-Shun HuangBioLegend, Inc., San Diego, CA, USA.
Ellen A RobeyUniversity of California, Berkeley, Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Berkeley, CA, USA. erobey@berkeley.edu.ORCID http://orcid.org/0000-0002-3630-5266
Nir YosefUniversity of California, Berkeley, Center for Computational Biology, Berkeley, CA, USA. nir.yosef@weizmann.ac.il.ORCID http://orcid.org/0000-0001-9004-1225
Aaron StreetsUniversity of California, Berkeley, Department of Bioengineering, Berkeley, CA, USA. astreets@berkeley.edu.ORCID http://orcid.org/0000-0002-3909-8389
University of California, Berkeley · USBerkeley College · USBioLegend (United States) · USBroad Institute · USMolecular Sciences Institute · USWeizmann Institute of Science · IL
Funding
Tool and Technology Development CoreU19MH114821 · NIMH · COLD SPRING HARBOR LABORATORY · PI MITRA, PARTHA PRATIM · 2017 to 2021
$64.5MSignals That Control Thymocyte MigrationR01AI064227 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI ELLEN A ROBEY · 2006 to 2026
$7.4MImmunology & Pathogenesis Program Training GrantT32AI100829 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI Gregory M Barton, ELLEN A ROBEY · 2012 to 2026
$4.7MOPTICAL, FLUIDIC, AND MOLECULAR TECHNOLOGIES FOR SINGLE-CELL OMICSR35GM124916 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Aaron Streets · 2017 to 2026
$3.4MSpatial and temporal mapping of cell fate within lymphoid tissueR24AI145816 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROBEY, ELLEN A, STREETS, AARON · 2020 to 2024
$3.2MNIAID NIH HHS R01 AI064227NIAID NIH HHS R24 AI145816NIAID NIH HHS T32 AI100829NIGMS NIH HHS R35 GM124916NIMH NIH HHS U19 MH114821
Abstract
The development of CD4
Indexed as
CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesAnimalsCD4 AntigensCell DifferentiationCell LineageHistocompatibility Antigens Class IMiceMice, TransgenicMultiomicsReceptors, Antigen, T-CellThymocytesThymus GlandCD4 AntigensHistocompatibility Antigens Class IReceptors, Antigen, T-Cell
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.