Evidence map›Paper›PMID 37580442›Full record

ArticleBritish journal of cancer2023

Focused ultrasound combined with miR-1208-equipped exosomes inhibits malignant progression of glioma.

Ying Zhan, Yichen Song, Wei Qiao, Lu Sun, Xin Wang, Bolong Yi, Xinyu Yang, Lian Ji, Peng Su, Wujun Zhao and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ying Zhan *Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Yichen Song *Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Wei QiaoDepartment of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Lu SunDepartment of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Xin WangDepartment of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Bolong YiDepartment of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Xinyu YangDepartment of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Lian JiLiaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Medical Research Center, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Peng SuLiaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Medical Research Center, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Wujun ZhaoDepartment of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Zhijun LiuDepartment of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Weidong RenDepartment of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, 110004, China. renwd01@126.com.ORCID 0000-0002-8422-7012
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExosomes (Exos) can safely and effectively deliver therapeutic substances to glioma cells; however, their blood-brain barrier (BBB) crossing capacity remains limited. Focused ultrasound (FUS) can transiently, reversibly, and locally open the BBB, while the effects of FUS combined with Exos-miRNA on the treatment of glioma have not been explored to date.

methodsExos were extracted by differential centrifugation and the efficacy of miR-1208-loaded Exos combined with FUS in the treatment of glioma was detected by CCK-8, colony formation, flow cytometry, transwell and tumour xenografts assays. The METTL3-mediated regulation of IGF2BP2 on mRNA stability of NUP214 was determined by MeRIP-qPCR, half-life and RIP assays.

resultsWe used Exos secreted by mesenchymal stem cells as carriers for the tumour suppressor gene miR-1208, and following FUS irradiation, more Exos carrying miR-1208 were allowed to pass through the BBB, and the uptake of miR-1208 in Exos by glioma cells was promoted, thereby achieving high-efficiency tumour-suppressive effects. Furthermore, the molecular mechanism underlying this effect was elucidated that miR-1208 downregulated the m

conclusionsMiR-1208-loaded Exos combined with FUS is expected to become an effective glioma treatment and deserves further clinical evaluation.

Indexed as

ExosomesGliomaMesenchymal Stem CellsMicroRNAsBlood-Brain BarrierHumansMethyltransferasesRNA-Binding ProteinsIGF2BP2 protein, humanMethyltransferasesMETTL3 protein, humanMicroRNAsMIRN1208 microRNA, humanRNA-Binding Proteins

Identifiers

PMID37580442
PMCPMC10539517
OpenAlexW4385800312

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.