Evidence map›Paper›PMID 37580403›Full record

ArticleJournal of cancer research and clinical oncology2023

A cohort study investigating the role of Bisphenol A in the molecular pathogenesis of breast cancer.

Ayesha Ishtiaq, Maryam Anyat Nasrullah, Jahangir Sarwar Khan, Sara Malik, Usman Tareen, Mariam Anees, Aneesa Sultan, Iram Murtaza

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ayesha IshtiaqSignal Transduction Laboratory, Department of Biochemistry, Quaid-i-Azam University Islamabad, Islamabad, 45320, Pakistan. ayesha@bs.qau.edu.pk.ORCID http://orcid.org/0000-0003-1244-3223
Maryam Anyat NasrullahDepartment of Biochemistry, Quaid-I-Azam University Islamabad, Islamabad, 45320, Pakistan.
Jahangir Sarwar KhanRawalpindi Medical University, Rawalpindi, Pakistan.
Sara MalikRawalpindi Medical University, Rawalpindi, Pakistan.
Usman TareenDepartment of Biochemistry, Quaid-I-Azam University Islamabad, Islamabad, 45320, Pakistan.
Mariam AneesDepartment of Biochemistry, Quaid-I-Azam University Islamabad, Islamabad, 45320, Pakistan.
Aneesa SultanDepartment of Biochemistry, Quaid-I-Azam University Islamabad, Islamabad, 45320, Pakistan. aneesa@qau.edu.pk.
Iram MurtazaSignal Transduction Laboratory, Department of Biochemistry, Quaid-i-Azam University Islamabad, Islamabad, 45320, Pakistan. irambch@qau.edu.pk.
Quaid-i-Azam University · PKRawalpindi Medical University · PK

Funding

Higher Education Commision, Pakistan HECQuaid-i-Azam University URF
6 · The paper itself

Abstract

backgroundBreast cancer is an abnormal division of breast cells. Bisphenol A (BPA), an environmental toxicant, is identified as an emerging risk factor for breast cancer development. However, to the best of our knowledge, no previous study has investigated the BPA levels in breast cancer patients in Pakistan. The present study sought to explore the role of BPA in tumor growth among the Pakistani population.

methodsThe levels of BPA were analyzed in the serum samples of breast cancer patients and controls by using HPLC. To elucidate the role of BPA to initiate tumorigenic events in breast tissue different biochemical assays along with expression analysis of tumor markers were performed.

resultsThe level of BPA in the serum samples of breast cancer patients was significantly higher than control. Histological analysis of breast cancer tissue samples revealed distinct subtypes of tumor, such as ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC). There was a significant increase in ROS level while a significant decrease in the levels of superoxide dismutase (SOD) and catalase (CAT) enzymes in malignant breast tissue samples as compared to control tissue samples. We found upregulated expression of p53, ZEB1 and WNT1 genes at mRNA level in malignant breast tissue samples by 17 folds, 328 folds and 35 folds, respectively. p53 protein expression in malignant breast tissue samples was also enhanced at the translational level.

conclusionCurrent findings suggest a relationship between BPA and the progression of breast cancer among the Pakistani population.

Indexed as

Breast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingBisphenol A CompoundsCohort StudiesFemaleHumansTumor Suppressor Protein p53bisphenol ABisphenol A CompoundsTumor Suppressor Protein p53Bisphenol ABreast cancerEnvironmental toxicantOxidative stressPakistan

Identifiers

PMID37580403
PMCPMC11798054
OpenAlexW4385803007

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.