Evidence map›Paper›PMID 37580341›Full record

ArticleNature communications2023

Efficient electrospray deposition of surfaces smaller than the spray plume.

Sarah H Park, Lin Lei, Darrel D'Souza, Robert Zipkin, Emily T DiMartini, Maria Atzampou, Emran O Lallow, Jerry W Shan, Jeffrey D Zahn, David I Shreiber and 3 more

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sarah H ParkDepartment of Materials Science and Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.ORCID http://orcid.org/0009-0008-4719-6107
Lin LeiDepartment of Mechanical and Aerospace Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
Darrel D'SouzaDepartment of Mechanical and Aerospace Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
Robert ZipkinMedChem 101 LLC, Plymouth Meeting, PA, USA.ORCID http://orcid.org/0009-0002-3729-7760
Emily T DiMartiniDepartment of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.ORCID http://orcid.org/0000-0003-0239-4819
Maria AtzampouDepartment of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
Emran O LallowDepartment of Mechanical and Aerospace Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
Jerry W ShanDepartment of Mechanical and Aerospace Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.ORCID http://orcid.org/0000-0003-2174-3930
Jeffrey D ZahnDepartment of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.ORCID http://orcid.org/0000-0001-8712-752X
David I ShreiberDepartment of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
Hao LinDepartment of Mechanical and Aerospace Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.ORCID http://orcid.org/0000-0003-4771-4353
Joel N MaslowGeneOne Life Science, Seoul, South Korea.
Jonathan P SingerDepartment of Materials Science and Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA. jonathan.singer@rutgers.edu.ORCID http://orcid.org/0000-0002-5934-8795

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrospray deposition (ESD) is a promising technique for depositing micro-/nano-scale droplets and particles with high quality and repeatability. It is particularly attractive for surface coating of costly and delicate biomaterials and bioactive compounds. While high efficiency of ESD has only been successfully demonstrated for spraying surfaces larger than the spray plume, this work extends its utility to smaller surfaces. It is shown that by architecting the local "charge landscape", ESD coatings of surfaces smaller than plume size can be achieved. Efficiency approaching 100% is demonstrated with multiple model materials, including biocompatible polymers, proteins, and bioactive small molecules, on both flat and microneedle array targets. UV-visible spectroscopy and high-performance liquid chromatography measurements validate the high efficiency and quality of the sprayed material. Here, we show how this process is an efficient and more competitive alternative to other conformal coating mechanisms, such as dip coating or inkjet printing, for micro-engineered applications.

Identifiers

PMID37580341
PMCPMC10425365

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.