Evidence map›Paper›PMID 37580184›Full record

ArticleJournal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi2023

Predicting stringent QuantiFERON-TB Gold Plus conversions in contacts of tuberculosis patients.

Sheng-Wei Pan, Donald G Catanzaro, Marva Seifert, Rehan R Syed, Naomi Hillery, Mei-Lin Ho, Valeriu Crudu, Elena Tudor, Nelly Ciobanu, Alexandru Codreanu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Sheng-Wei PanDepartment of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Donald G CatanzaroDepartment of Biological Sciences, University of Arkansas, Fayetteville, AR, USA. Electronic address: dgcatanz@uark.edu.
Marva SeifertDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Rehan R SyedDivision of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Naomi HilleryThe Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA.
Mei-Lin HoDepartment of Chemistry, Fu Jen Catholic University, New Taipei City, Taiwan.
Valeriu CruduThe Chiril Draganiuc Institute of Phthisiopneumology, Chisinau, Republic of Moldova.
Elena TudorThe Chiril Draganiuc Institute of Phthisiopneumology, Chisinau, Republic of Moldova.
Nelly CiobanuThe Chiril Draganiuc Institute of Phthisiopneumology, Chisinau, Republic of Moldova.
Alexandru CodreanuThe Chiril Draganiuc Institute of Phthisiopneumology, Chisinau, Republic of Moldova.
Antonino CatanzaroDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Timothy C RodwellDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Phthisiopneumology Institute "Chiril Draganiuc" · MDUniversity of California System · USUniversity of California San Diego · USFu Jen Catholic University · TWNational Yang Ming Chiao Tung University · TWUniversity of Arkansas at Fayetteville · US

Funding

HOPE Training GrantT32AI007384 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sara Gianella Weibel, Scott L Letendre · 1990 to 2026
$9.7M
Identifying individuals at risk of progression to active tuberculosisR01AI137681 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CATANZARO, ANTONINO, RODWELL, TIMOTHY CHARLES · 2018 to 2022
$3.7M
NIAID NIH HHS R01 AI137681NIAID NIH HHS T32 AI007384
6 · The paper itself

Abstract

objectivesTo assess associations between disease severity in index TB patients and QuantiFERON-TB Gold Plus (QFT-Plus) results in contacts, and predictors for QFT-Plus conversion in contacts over 6-12 months.

methodsTB patients (n = 295) and the contacts (n = 1051) were enrolled during 2018-2021 with QFT-Plus performed at baseline and months 6 and 12. A strong CD8 response was defined as TB2 interferon gamma (IFN-γ) response minus TB1 >0.6 IU/ml and stringent conversion as change from QFT-plus negative to high-positive QFT-Plus (TB1 or TB2 IFN-γ responses >0.7 IU/ml).

resultsContacts with index TB patients with sputum smear >1+ was associated with positive QFT-Plus compared to those without (p < 0.001). Contacts with index TB patients with bilateral lung disease were more likely to have strong CD8 responses than those without (p = 0.038). QFT-Plus stringent conversion occurred in 9.7% of contacts over 6-12 months. A TB1 IFN-γ response ≥0.03 IU/ml combined with a TB2 ≥0.06 IU/ml was predictive of a 19-fold increased risk for QFT-Plus stringent conversion in contacts (odd ratio 19.565 [8.484-45.116], p < 0.001).

conclusionBacterial burden and bilateral lung disease of index TB patients were associated with positive QFT-Plus and strong CD8 responses in contacts. TB1 and TB2 IFN-γ responses were synergistically predictive of stringent conversion in contacts.

Indexed as

Latent TuberculosisLung DiseasesMycobacterium tuberculosisTuberculosisHumansInterferon-gammaInterferon-gamma Release TestsTuberculin TestInterferon-gammaInterferon-gamma release assayQuantiFERON-TB Gold plusStringent conversionTuberculosis contacts

Identifiers

PMID37580184
PMCPMC10604336
OpenAlexW4385598127

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.