Evidence map›Paper›PMID 37579984›Full record

ArticleBiochimica et biophysica acta. General subjects2023

Small molecule inhibitors of the fosfomycin resistance enzyme FosM from Mycobacterium abscessus.

Skye Chiasson, Tatum Smith, Landon Bello, Nishad Thamban Chandrika, Keith D Green, Sylvie Garneau-Tsodikova, Matthew K Thompson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. General subjects, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Skye ChiassonDepartment of Chemistry & Biochemistry, The University of Alabama, 250 Hackberry Lane, Tuscaloosa, AL 35487, United States of America.
Tatum SmithDepartment of Chemistry & Biochemistry, The University of Alabama, 250 Hackberry Lane, Tuscaloosa, AL 35487, United States of America.
Landon BelloDepartment of Chemistry & Biochemistry, The University of Alabama, 250 Hackberry Lane, Tuscaloosa, AL 35487, United States of America.
Nishad Thamban ChandrikaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone St., Lexington, KY 40536, United States of America.
Keith D GreenDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone St., Lexington, KY 40536, United States of America.
Sylvie Garneau-TsodikovaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone St., Lexington, KY 40536, United States of America.
Matthew K ThompsonDepartment of Chemistry & Biochemistry, The University of Alabama, 250 Hackberry Lane, Tuscaloosa, AL 35487, United States of America. Electronic address: mthompson10@ua.edu.
University of Alabama · USUniversity of Kentucky · US

Funding

Combating Fosfomycin Resistance in Methicillin-Resistant Staphylococcus aureusR15GM148956 · NIGMS · UNIVERSITY OF ALABAMA IN TUSCALOOSA · PI THOMPSON, MATTHEW KYLE · 2022 to 2022
$430k
NIGMS NIH HHS R15 GM148956
6 · The paper itself

Abstract

Fosfomycin is a safe broad-spectrum antibiotic that has not achieved widespread use because of the emergence of fosfomycin-modifying enzymes. Inhibition of fosfomycin-modifying enzymes could be used to help combat pathogens like Mycobacterium abscessus. Our previous work identified several inhibitors for the enzyme FosB from Staphylococcus aureus. We have tested those same compounds for inhibition of FosM, the fosfomycin-modifying enzyme from M. abscessus. The work described here will be used as the basis for more detailed studies into the inhibition of FosM.

Indexed as

FosfomycinMycobacterium abscessusStaphylococcal InfectionsAnti-Bacterial AgentsHumansStaphylococcus aureusAnti-Bacterial AgentsFosfomycinAntimicrobial resistanceForMFosfomycinMycobacterium abscessus

Identifiers

PMID37579984
PMCPMC10727124
OpenAlexW4385782104

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.