Evidence map›Paper›PMID 37579983›Full record

ArticleBiochimica et biophysica acta. Molecular basis of disease2023

Iron promotes glycolysis to drive colon tumorigenesis.

Zhaoli Liu, Luke Villareal, Lavanya Goodla, Hyeoncheol Kim, Daniel M Falcon, Mohammad Haneef, David R Martin, Li Zhang, Ho-Joon Lee, Daniel Kremer and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Molecular basis of disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Zhaoli LiuDepartment of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM 87131, USA.
Luke VillarealDepartment of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM 87131, USA.
Lavanya GoodlaDepartment of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM 87131, USA.
Hyeoncheol KimDepartment of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM 87131, USA.
Daniel M FalconDepartment of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM 87131, USA.
Mohammad HaneefDepartment of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM 87131, USA.
David R MartinDepartment of Pathology, University of New Mexico, Albuquerque, NM 87131, USA.
Li ZhangDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Ho-Joon LeeDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Daniel KremerDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Costas A LyssiotisDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Yatrik M ShahDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.
Henry C LinSection of Gastroenterology, Medicine Service, New Mexico VA Health Care System, Albuquerque, NM 87108, USA; Division of Gastroenterology and Hepatology, Department of Medicine, the University of New Mexico, Albuquerque, NM, 87131, USA.
Hui-Kuan LinDepartment of Pathology, Duke University, Durham, NC 27710, USA.
Xiang XueDepartment of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: xxue@salud.unm.edu.
University of New Mexico · USUniversity of Michigan–Ann Arbor · USDuke University · US

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
University of New Mexico Center for Metals in Biology and Medicine - equipment supplementP20GM130422 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Eliane El Hayek · 2020 to 2026
$20.4M
FAIR Data Competency and Machine Learning Readiness for Biomedical ScientistsK12GM088021 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI REBECCA S. HARTLEY, Diane Lidke · 2009 to 2026
$16.4M
Stromal metabolism promotes therapeutic resistance in pancreatic cancerR01CA248160 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LYSSIOTIS, COSTAS ANDREAS · 2020 to 2024
$2.0M
Targeting metabolic stress to induce pancreatic tumor cell deathR01CA244931 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LYSSIOTIS, COSTAS ANDREAS · 2020 to 2024
$1.9M
NCI NIH HHS P30 CA118100NCI NIH HHS R01 CA244931NCI NIH HHS R01 CA248160NIGMS NIH HHS K12 GM088021NIGMS NIH HHS P20 GM130422
6 · The paper itself

Abstract

Colorectal cancer (CRC) is the third most common cancer and is also the third leading cause of cancer-related death in the USA. Understanding the mechanisms of growth and progression of CRC is essential to improve treatment. Macronutrients such as glucose are energy source for a cell. Many tumor cells exhibit increased aerobic glycolysis. Increased tissue micronutrient iron levels in both mice and humans are also associated with increased colon tumorigenesis. However, if iron drives colon carcinogenesis via affecting glucose metabolism is still not clear. Here we found the intracellular glucose levels in tumor colonoids were significantly increased after iron treatment.

Indexed as

IronNeoplasmsAnimalsCarcinogenesisCell Transformation, NeoplasticColonGlucoseGlucose Transporter Type 1GlycolysisHumansMiceGlucoseGlucose Transporter Type 1IronGlucoseGLUT1IronPDHPDHK3Tankyrase

Identifiers

PMID37579983
PMCPMC10530594
OpenAlexW4385782840

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.