ArticleAmerican journal of epidemiology2023
Associations of Early-Life Adversity With Later-Life Epigenetic Aging Profiles in the Multi-Ethnic Study of Atherosclerosis.
Article in American journal of epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- The impact of adverse childhood experiences on DNA methylation age: a systematic review and meta-analysis.Clinical epigenetics · 2026Pooled it
- Life-course Psychosocial Adversity and Biological Aging in the Hispanic Community Health Study / Study of Latinos: A Life-course Model Analysis.Research square · 2026Article
- Epigenetic Aging Clocks and Incident Cardiovascular Outcomes: Results From the MESA.Journal of the American Heart Association · 2025Article
- Impact of psychosocial stress in early life on pace of aging in young adulthood.Clinical epigenetics · 2025Article
- The role of stress proliferation in linking childhood stressors to accelerated biological aging.Social science & medicine (1982) · 2025Article
- Childhood Adversity and Cardiovascular Disease; Current Knowledge and Future Directions.Current cardiology reports · 2025Review
- Epigenetic biomarkers of socioeconomic status are associated with age-related chronic diseases and mortality in older adults.PNAS nexus · 2025Article
- Adverse Childhood Experiences and Accelerated Epigenetic Aging in the Hispanic Community Health Study/Study of Latinos: Nativity as an Effect Modifier.Psychoneuroendocrinology · 2025Article
- Childhood adversity, accelerated GrimAge, and associated health consequences.Journal of behavioral medicine · 2024Article
- Childhood Maltreatment and Biological Aging in Middle Adulthood: The Role of Psychiatric Symptoms.Biological psychiatry global open science · 2024Article
- Parental Divorce in Childhood and the Accelerated Epigenetic Aging for Earlier and Later Cohorts: Role of Mediators of Chronic Depressive Symptoms, Education, Smoking, Obesity, and Own Marital Disruption.Journal of population ageing · 2024Article
- Generations of epigenetic clocks and their links to socioeconomic status in the Health and Retirement Study.Epigenomics · 2024Article
- Poverty Status at Birth Predicts Epigenetic Changes at Age 15.Journal of biomedical and life sciences · 2024Article
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
Epigenetic biomarkers of accelerated aging have been widely used to predict disease risk and may enhance our understanding of biological mechanisms between early-life adversity and disparities in aging. With respect to childhood adversity, most studies have used parental education or childhood disadvantage and/or have not examined the role played by socioemotional or physical abuse and trauma in epigenetic profiles at older ages. This study leveraged data from the Multi-Ethnic Study of Atherosclerosis (MESA) on experiences of threat and deprivation in participants' early lives (i.e., before the age of 18 years) to examine whether exposure to specific dimensions of early-life adversity is associated with epigenetic profiles at older ages that are indicative of accelerated biological aging. The sample included 842 MESA respondents with DNA methylation data collected between 2010 and 2012 who answered questions on early-life adversities in a 2018-2019 telephone follow-up. We found that experiences of deprivation, but not threat, were associated with later-life GrimAge epigenetic aging signatures that were developed to predict mortality risk. Results indicated that smoking behavior partially mediates this association, which suggests that lifestyle behaviors may act as downstream mechanisms between parental deprivation in early life and accelerated epigenetic aging in later life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.