Evidence map›Paper›PMID 37578953›Full record

ArticlePLOS global public health2023

Impact of the COVID-19 pandemic on the provision and uptake of services for the prevention of mother-to-child transmission of HIV in Zimbabwe.

Elizabeth Chappell, Anesu Chimwaza, Ngoni Manika, Catherine J Wedderburn, Zivai Mupambireyi Nenguke, Hannah Gannon, Frances Cowan, Tom Gibb, Michelle Heys, Felicity Fitzgerald and 6 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in PLOS global public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04782739 (Evaluation of the Impact of the COVID-19 Pandemic on Provision and Uptake of Services for the Prevention of Mother-to-child Transmission of HIV and Syphilis in Zimbabwe), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04782739 completednot on this map

Evaluation of the Impact of the COVID-19 Pandemic on Provision and Uptake of Services for the Prevention of Mother-to-child Transmission of HIV and Syphilis in Zimbabwe

TypeobservationalSponsorUniversity of ZimbabweRan2021 to 2022Enrolled30ConditionsHIV Infections, SyphilisArmsNone - Descriptive study
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

Elizabeth ChappellMRC Clinical Trials Unit at UCL, London, United Kingdom.ORCID https://orcid.org/0000-0003-1053-6434
Anesu ChimwazaMinistry of Health and Child Care, Harare, Zimbabwe.
Ngoni ManikaMinistry of Health and Child Care, Harare, Zimbabwe.
Catherine J WedderburnMRC Clinical Trials Unit at UCL, London, United Kingdom.ORCID https://orcid.org/0000-0002-4887-1644
Zivai Mupambireyi NengukeCentre for Sexual Health and HIV/AIDS Research (CeSHHAR), Harare, Zimbabwe.
Hannah GannonUCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
Frances CowanCentre for Sexual Health and HIV/AIDS Research (CeSHHAR), Harare, Zimbabwe.ORCID https://orcid.org/0000-0003-3087-4422
Tom GibbPicturing Health, United Kingdom.
Michelle HeysUCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom.
Felicity FitzgeraldDepartment of Infectious Disease, Imperial College London, London, United Kingdom.ORCID https://orcid.org/0000-0001-9594-3228
Andrew PhillipsInstitute for Global Health, UCL, London, United Kingdom.
Simbarashe ChimhuyaChild and Adolescent Health Unit, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.
Diana M GibbMRC Clinical Trials Unit at UCL, London, United Kingdom.
Deborah FordMRC Clinical Trials Unit at UCL, London, United Kingdom.ORCID https://orcid.org/0000-0003-1713-6302
Angela MushaviMinistry of Health and Child Care, Harare, Zimbabwe.
Mutsa Bwakura-DangarembiziChild and Adolescent Health Unit, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.ORCID https://orcid.org/0000-0001-7751-6177
Ministry of Health and Child Welfare · ZWMRC Clinical Trials Unit at UCL · GBUniversity College London · GBUniversity of Zimbabwe · ZWCentre for Sexual Health and HIV AIDS Research · ZWImperial College London · GBLiverpool School of Tropical Medicine · GBUniversity of Cape Town · ZA

Funding

Medical Research Council MC_U122886353Medical Research Council MC_UU_00004/03Medical Research Council MC_UU_12023/17Medical Research Council MC_UU_12023/26Medical Research Council MR/V029126/1
6 · The paper itself

Abstract

Zimbabwe is targeting elimination of mother-to-child transmission of HIV by December 2025, however the COVID-19 pandemic challenged health service delivery globally. Monthly aggregated data were extracted from DHIS-2 for all facilities delivering antenatal care (ANC). ZIMSTAT and Spectrum demographic estimates were used for population-level denominators. Programme indicators are among those in HIV care and population indicators reflect the total population. The mean estimated proportion of pregnant women booking for ANC per month did not change (91% pre-pandemic vs 91% during pandemic, p = 0.95), despite dropping to 47% in April 2020. At a programme-level, the estimated proportion of women who received at least one HIV test fell in April 2020 (3.6% relative reduction vs March (95% CI 2.2-5.1), p<0.001) with gradual recovery towards pre-pandemic levels. The estimated proportion of women who were retested among those initially negative in pregnancy fell markedly in April 2020 (39% reduction (32-45%), p<0.001) and the subsequent increase was much slower, only reaching 39% by September 2021 compared to average 53% pre-pandemic. The mean estimated proportion of pregnant women with HIV on ART was unchanged at programme-level (98% vs 98%, p = 0.26), but decreased at population-level (86% vs 80%, p = 0.049). Antiretroviral prophylaxis coverage decreased among HIV-exposed infants, at programme- (94% vs 87%, p = 0.001) and population-levels (76% vs 68%, p<0.001). There was no significant change in HIV-exposed infants receiving EID (programme: 107% vs 103%, p = 0.52; population: 87% vs 79%, p = 0.081). The estimated proportion of infants with HIV diagnosed fell from 27% to 18%, (p<0.001), while the estimated proportion on ART was stable at a programme (88% vs 90%, p = 0.82) but not population (22% vs 16%, p = 0.004) level. Despite a drop at the start of the pandemic most programme indicators rapidly recovered. At a population-level indicators were slower to return, suggesting less women with HIV identified in care.

Identifiers

PMID37578953
PMCPMC10424857
OpenAlexW4385802432

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.