Evidence map›Paper›PMID 37578729›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Theoretical 3D Modeling of NLRP3 Inflammasome Complex.

Patricia Mirela Bota, Baldo Oliva, Narcis Fernandez-Fuentes

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Patricia Mirela BotaStructural Bioinformatics Lab (GRIB-IMIM), Department of Experimental and Health Science, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain.
Baldo OlivaStructural Bioinformatics Lab (GRIB-IMIM), Department of Experimental and Health Science, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain. baldo.oliva@upf.edu.
Narcis Fernandez-FuentesInstitute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, UK.
Pompeu Fabra University · ESInstitute of Biological, Environmental and Rural Sciences · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The NOD-like receptor pyrin domain containing 3 (NLRP3) is a multidomain protein that plays a key role in innate immune response. Structures of NLRP3 in different conformational states and bound to cognate partners are available. In this chapter we present an approach to model the oligomeric structure of NLRP3 by homology modeling using multiple templates, symmetry, and refinement. The overall process presented here represents advanced exercise in structural modeling that provides unique insights into the biological role and activation of NLRP3 oligomer. Finally, the same approach can be easily adapted to the rest of the members of the NLRP family.

Indexed as

InflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinImmunity, InnateMolecular ConformationMolecular Dynamics SimulationInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinDe novo modelling of multidomain/multimeric NLRP3Homology modellingStructure of inflammasome complexStructure refinement

Identifiers

PMID37578729
OpenAlexW4385799204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.