Evidence map›Paper›PMID 37578713›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Inflammasome-Independent Roles of NLR and ALR Family Members.

Suman Gupta, Suzanne L Cassel, Fayyaz S Sutterwala

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Suman GuptaDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Suzanne L CasselDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Fayyaz S SutterwalaDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA. fayyaz.sutterwala@cshs.org.
Cedars-Sinai Medical Center · US

Funding

Mitochondrial regulation of the NLRP3 inflammasome in myocardial ischemia-reperfusion injury and heart transplantationR21AI156919 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI SUTTERWALA, FAYYAZ S. · 2021 to 2022
$459k
NIAID NIH HHS R21 AI156919
6 · The paper itself

Abstract

Pattern recognition receptors, including members of the NLR and ALR families, are essential for recognition of both pathogen- and host-derived danger signals. Several members of these families, including NLRP1, NLRP3, NLRC4, and AIM2, are capable of forming multiprotein complexes, called inflammasomes, that result in the activation of pro-inflammatory caspase-1. However, in addition to the formation of inflammasomes, a number of these family members exert inflammasome-independent functions. Here, we will discuss inflammasome-independent functions of NLRC4, NLRP12, and AIM2 and examine their roles in regulating innate and adaptive immune processes.

Indexed as

InflammasomesReceptors, Pattern RecognitionFamilyHumansImmunityNLR Family, Pyrin Domain-Containing 3 ProteinInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinReceptors, Pattern RecognitionAIM2Caspase-1InflammasomeNLRC4NLRP12

Identifiers

PMID37578713
OpenAlexW4385798234

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.