Evidence map›Paper›PMID 37578679›Full record

ArticleMolecular neurobiology2024

Gene Interaction of Dopaminergic Synaptic Pathway Genes in Attention-Deficit Hyperactivity Disorder: a Case-Control Study in Chinese Children.

Lin Zhong, Hongyao He, Jing Zhang, Xiaoyan Gao, Feifei Yin, Pengxiang Zuo, Ranran Song

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Phytoconstituents ofACS omega · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lin ZhongMedical College of Shihezi University, Xinjiang, Shihezi, 832000, China.
Hongyao HeMedical College of Shihezi University, Xinjiang, Shihezi, 832000, China.
Jing ZhangMedical College of Shihezi University, Xinjiang, Shihezi, 832000, China.
Xiaoyan GaoMedical College of Shihezi University, Xinjiang, Shihezi, 832000, China.
Feifei YinMedical College of Shihezi University, Xinjiang, Shihezi, 832000, China.
Pengxiang ZuoMedical College of Shihezi University, Xinjiang, Shihezi, 832000, China. zuo_pengxiang@sina.com.ORCID http://orcid.org/0000-0001-9021-4050
Ranran SongDepartment of Maternal and Child Health and MOE Key Lab of Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, 430000, China. songranran@hust.edu.cn.
Shihezi University · CNHuazhong University of Science and Technology · CN

Funding

the National Natural Science Foundation of China 81760597
6 · The paper itself

Abstract

Attention-deficit hyperactivity disorder is a highly inherited neurodevelopmental disorder. Previous genetic research has linked ADHD to certain genes in the dopaminergic synaptic pathway. Nonetheless, research on this relationship has produced varying results across various populations. China is a multi-ethnic country with its own unique genetic characteristics. Therefore, such a population can provide useful information about the relationship between gene polymorphisms in dopaminergic synaptic pathways and ADHD. This study looked at the genetic profiles of 284 children in China's Xinjiang. In total, 142 ADHD children and 142 control subjects were enrolled. Following the extraction of DNA from oral mucosal cells, 13 SNPs for three candidate genes (SLC6A3, DRD2, and GRIN2B) in the dopaminergic synaptic pathway of ADHD were screened. Based on the results of single nucleotide polymorphism (SNP) analyses, we found that the DRD2 gene variants rs6277 and rs6275, and the SLC6A3 gene variant rs2652511, were significantly associated with ADHD in boys and girls, respectively, after adjusting for false discovery rate (FDR) in terms of allele frequencies. Furthermore, our generalized multifactorial downscaling approach identified a significant association between rs6275 and rs1012586. These findings suggest that DRD2 and SLC6A3 genes have a crucial role in ADHD susceptibility. Additionally, we observed that the interaction between GRIN2B and DRD2 genes may contribute to the susceptibility of Chinese children with ADHD.

Indexed as

Attention Deficit Disorder with HyperactivityDopamine Plasma Membrane Transport ProteinsReceptors, Dopamine D2Receptors, N-Methyl-D-AspartateCase-Control StudiesChildEast Asian PeopleFemaleGene FrequencyGenetic Predisposition to DiseaseHumansMalePolymorphism, Single NucleotideDopamine Plasma Membrane Transport ProteinsDRD2 protein, humanNR2B NMDA receptorReceptors, Dopamine D2Receptors, N-Methyl-D-AspartateSLC6A3 protein, humanAttention-deficit hyperactivity disorderDopaminergic synapse pathway genesDRD2, SLC6A3GRIN2BInteraction

Identifiers

PMID37578679
PMCPMC10791714
OpenAlexW4385798497

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.