Evidence map›Paper›PMID 37578643›Full record

ArticleCurrent microbiology2023

Association of 3p21.31 Locus (CXCR6 and LZTFL1) with COVID-19 Outcomes in Brazilian Hospitalyzed Subjects.

João Locke Ferreira de Araújo, Victória Frigério Bonifácio, Lorena Medeiros Batista, Renata Eliane de Ávila, Renato Santana Aguiar, Luciana Bastos-Rodrigues, Renan Pedra de Souza

Abstract read
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In one paragraph

Article in Current microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

João Locke Ferreira de AraújoGrupo de Pesquisa em Bioestatística e Epidemiologia Molecular, Laboratório de Biologia Integrativa, Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Victória Frigério BonifácioDepartamento de Nutrição, Escola de Enfermagem, Universidade Federal de Minas Gerais, Minas Gerais - Brazil, Belo Horizonte, MG, Brazil.
Lorena Medeiros BatistaDepartamento de Nutrição, Escola de Enfermagem, Universidade Federal de Minas Gerais, Minas Gerais - Brazil, Belo Horizonte, MG, Brazil.
Renata Eliane de ÁvilaHospital Eduardo de Menezes, Belo Horizonte, MG, Brazil.
Renato Santana AguiarGrupo de Pesquisa em Bioestatística e Epidemiologia Molecular, Laboratório de Biologia Integrativa, Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Luciana Bastos-RodriguesDepartamento de Nutrição, Escola de Enfermagem, Universidade Federal de Minas Gerais, Minas Gerais - Brazil, Belo Horizonte, MG, Brazil. lu.bastosr@gmail.com.
Renan Pedra de SouzaGrupo de Pesquisa em Bioestatística e Epidemiologia Molecular, Laboratório de Biologia Integrativa, Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. renanpedra@gmail.com.
Universidade Federal de Minas Gerais · BRFundação Hospitalar do Estado de Minas Gerais · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico Conselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível Superior Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFinanciadora de Estudos e Projetos Financiadora de Estudos e ProjetosFundação de Amparo à Pesquisa do Estado de Minas Gerais Fundação de Amparo à Pesquisa do Estado de Minas Gerais
6 · The paper itself

Abstract

The 3p21.31 locus has been associated with severe COVID-19 prognosis in GWAS studies. Here, we evaluated whether three polymorphisms (LZTFL1 rs10490770, CXCR6 rs2234355 and rs2234358) in the reported locus were associated with the need for mechanical ventilation, hospitalization length and death in 102 COVID-19 hospitalized Brazilian subjects. No genetic association was found with the need for mechanical ventilation and hospitalization length. CXCR6 rs2234355 was associated with mortality under the codominance model, with carriers of the A/A genotype having a greater chance of death than A/G (OR: 10.5; 95% CI: 1.55-70.76). Our results further suggest that the CXCR6 genetic variant contributes to COVID-19 outcomes.

Indexed as

COVID-19BrazilGenotypeHospitalizationHumansReceptors, CXCR6Transcription FactorsCXCR6 protein, humanLZTFL1 protein, humanReceptors, CXCR6Transcription Factors

Identifiers

PMID37578643
OpenAlexW4385797887

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.