Evidence map›Paper›PMID 37578565›Full record

ArticleDigestive diseases and sciences2023

Coronavirus Disease 2019 (COVID-19) Pandemic Lifestyle Changes May Have Influenced Small Bowel Microbial Composition and Microbial Resistance.

Ava Hosseini, Mohamad Rashid, Gabriela Leite, Gillian M Barlow, Gonzalo Parodi, Maritza Sanchez, Sarah Ayyad, Maya L Pimentel, Walter Morales, Stacy Weitsman and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ava Hosseini *Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Mohamad Rashid *Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Gabriela LeiteMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Gillian M BarlowMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Gonzalo ParodiMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Maritza SanchezMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Sarah AyyadMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Maya L PimentelMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Walter MoralesMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Stacy WeitsmanMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Mark PimentelMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Ruchi MathurMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA. ruchi.mathur@cshs.org.ORCID http://orcid.org/0000-0003-1053-6557
Cedars-Sinai Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe coronavirus disease 2019 (COVID-19) global pandemic necessitated many severe lifestyle changes, including lockdowns, social distancing, altered food consumption and exercise patterns, and extensive hygiene practices. These extensive changes may have affected the human gut microbiome, which is highly influenced by lifestyle.

aimsTo examine the potential effects of pandemic-related lifestyle changes on the metabolically relevant small bowel microbiome.

methodsAdult subjects presenting for upper endoscopy without colonoscopy were identified and divided into two matched groups: pre-pandemic (February 2019-March 2020) and intra-pandemic (April 2021-September 2021, all COVID-19 negative). Duodenal aspirates and blood samples were collected. Duodenal microbiomes were analyzed by 16S rRNA sequencing. Serum cytokine levels were analyzed by Luminex FlexMap3D.

resultsFifty-six pre-pandemic and 38 COVID-negative intra-pandemic subjects were included. There were no significant changes in duodenal microbial alpha diversity in the intra-pandemic vs. pre-pandemic group, but beta diversity was significantly different. The relative abundance (RA) of phylum Deinococcus-Thermus and family Thermaceae, which are resistant extremophiles, was significantly higher in the intra-pandemic vs. pre-pandemic group. The RA of several Gram-negative taxa including Bacteroidaceae (phylum Bacteroidetes) and the Proteobacteria families Enterobacteriaceae and Pseudomonadaceae, and the RA of potential disruptor genera Escherichia-Shigella and Rothia, were significantly lower in the intra-pandemic vs. pre-pandemic group. Circulating levels of interleukin-18 were also lower in the intra-pandemic group.

conclusionsThese findings suggest the small bowel microbiome underwent significant changes during the pandemic, in COVID-19-negative individuals. Given the key roles of the small bowel microbiota in host physiology, this may have implications for human health.

Indexed as

COVID-19PandemicsAdultBacteriaCommunicable Disease ControlHumansIntestine, SmallRNA, Ribosomal, 16SRNA, Ribosomal, 16SCOVID-19 pandemicDuodenumGut microbiomeLifestyle changes

Identifiers

PMID37578565
PMCPMC10516792
OpenAlexW4385798714

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.