SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2023
Does vertebral osteoporosis delay or accelerate lumbar disc degeneration? A systematic review.
Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Causal links between multi-domain risk factors and intervertebral disc degeneration: a systematic review and meta-analysis of Mendelian randomization studies.BMC musculoskeletal disorders · 2026Pooled it
- New evidence on the controversy over the correlation between vertebral osteoporosis and intervertebral disc degeneration: a systematic review of relevant animal studies.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Pooled it
- Association between lumbar vertebral body bone quality and cranial/caudal endplate bone quality with intervertebral disc degeneration: a retrospective study of 2018 patients.Journal of orthopaedic surgery and research · 2026Article
- Research on zoledronic acid's synergistic improvement of intervertebral disc degeneration and osteoporosis by regulating inflammation matrix microenvironment.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Severe Disc degeneration is associated with lower caudal subendplate hounsfield unit values in degenerative lumbar spinal stenosis.BMC musculoskeletal disorders · 2026Article
- Osteoporosis in adjacent cervical segments exacerbates disc herniation.Scientific reports · 2025Article
- Article
- Is There a Positive or Negative Correlation Between Cervical Vertebral Bone Quality and Intervertebral Disc Degeneration by Pfirrmann Grading.JOR spine · 2025Article
- The Degree of Cervical Intervertebral Disc Degeneration Is Associated With Denser Bone Quality of the Cervical Sub-endplate and Vertebral Body.Orthopaedic surgery · 2025Article
- Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice.Frontiers in pharmacology · 2025Article
- Evaluation of the effect of cervical spine bone distribution on fixation in ankylosing spondylitis.Frontiers in bioengineering and biotechnology · 2025Article
- Correlation analysis of osteoporosis and vertebral endplate defects using CT and MRI imaging: a retrospective cross-sectional study.Frontiers in physiology · 2025Article
- Association of vertebral fractures with worsening degenerative changes of the spine: a longitudinal study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Roles of organokines in intervertebral disc homeostasis and degeneration.Frontiers in endocrinology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of vertebral osteoporosis on disc degeneration is still debated. The purpose of this study was to provide a systematic review of studies in this area to further reveal the relationship between the two. Relevant studies were searched in electronic databases, and studies were screened according to inclusion and exclusion criteria, and finally, basic information of the included studies was extracted and summarized. This study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A total of 34 publications spanning 24 years were included in our study. There were 19 clinical studies, including 12 prospective studies and 7 retrospective studies. Of these, 7 considered vertebral osteoporosis to be positively correlated with disc degeneration, 8 considered them to be negatively correlated, and 4 considered them to be uncorrelated. Two cadaveric studies were included, one considered the two to be negatively correlated and one considered them not to be correlated. Seven animal studies were included, of which five considered a positive correlation between vertebral osteoporosis and disc degeneration and two considered a negative correlation between the two. There were also 6 studies that used anti-osteoporosis drugs for intervention, all of them were animal studies. Five of them concluded that vertebral osteoporosis was positively associated with disc degeneration, and the remaining one concluded that there was no correlation between the two. Our systematic review shows that the majority of studies currently consider an association between vertebral osteoporosis and disc degeneration, but there is still a huge disagreement whether this association is positive or negative. Differences in observation time and follow-up time may be one of the reasons for the disagreement. A large number of clinical and basic studies are still needed in the future to further explore the relationship between the two.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.