Evidence map›Paper›PMID 37578472›Full record

ArticleACS sensors2023

Hyperpolarized [1-

Jun Chen, Tamara K Singh, Sarah Al Nemri, Maheen Zaidi, Kelvin L Billingsley, Jae Mo Park

Open access · greenAbstract read
In one paragraph

Article in ACS sensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jun ChenAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Tamara K SinghDepartment of Chemistry and Biochemistry, California State University, Fullerton, California 92831, United States.
Sarah Al NemriAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Maheen ZaidiAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Kelvin L BillingsleyDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States.ORCID 0000-0001-9071-5170
Jae Mo ParkAdvanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.ORCID 0000-0002-7404-6971
Advanced Imaging Research (United States) · USCalifornia State University, Fullerton · USLoyola University Chicago · US

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
TR&D 3: Imaging Carbohydrate MetabolismP41EB015908 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2012 to 2021
$10.9M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeff G McDonald · 2022 to 2026
$7.4M
Pyruvate and acetate metabolism after TBI: implications for cerebral energy metabolismR01NS107409 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PARK, JAE MO · 2020 to 2024
$2.7M
Hyperpolarized 13C Probes for Imaging Warburg Metabolism in CancerSC1GM127213 · NIGMS · CALIFORNIA STATE UNIVERSITY FULLERTON · PI BILLINGSLEY, KELVIN L · 2018 to 2021
$1.3M
A Clinical Polarizer for Carbon-13 (SpinLab)S10OD018468 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI MALLOY, CRAIG R · 2015 to 2015
$1.0M
NIBIB NIH HHS P41 EB013598NIBIB NIH HHS P41 EB015908NIDDK NIH HHS P30 DK127984NIGMS NIH HHS SC1 GM127213NIH HHS S10 OD018468NINDS NIH HHS R01 NS107409
6 · The paper itself

Abstract

Mitochondrial oxidative phosphorylation (OXPHOS) is sensitive to a variety of biological factors, and dysregulated OXPHOS is observed during the development of numerous pathological conditions. ATP production via OXPHOS is intrinsically dependent on the availability of acetyl-coenzyme A (CoA), which can enter the tricarboxylic acid (TCA) cycle to drive the oxidative pathway. Acetyl-l-carnitine (ALCAR) is an interchangeable endogenous source of acetyl-CoA, and therefore, ALCAR-derived probes are uniquely positioned for the assessment of OXPHOS. In this report, we develop hyperpolarized (HP) [1-

Indexed as

AcetylcarnitineCitric Acid CycleAnimalsMitochondriaOxidation-ReductionRatsAcetylcarnitineacetyl-CoAacetyl-l-carnitinecarbon-13 MRScardiac oxidative metabolismhyperpolarizationoxidative phosphorylation

Identifiers

PMID37578472
PMCPMC11227661
OpenAlexW4385799228

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.