Evidence map›Paper›PMID 37578238›Full record

ArticleJournal of virology2023

A single dominant locus restricts retrovirus replication in YBR/Ei mice.

Helen A Beilinson, Amanda Sevilleja, Jessica Spring, Fernando Benavides, Vera Beilinson, Nickolas Neokosmidis, Tatyana Golovkina

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 66% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Helen A BeilinsonDepartment of Microbiology, University of Chicago , Chicago, Illinois, USA.ORCID 0000-0002-2888-5256
Amanda SevillejaCommittee on Immunology, University of Chicago , Chicago, Illinois, USA.
Jessica SpringCommittee on Microbiology, University of Chicago , Chicago, Illinois, USA.
Fernando BenavidesDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center , Houston, Texas, USA.
Vera BeilinsonDepartment of Microbiology, University of Chicago , Chicago, Illinois, USA.
Nickolas NeokosmidisDepartment of Microbiology, University of Chicago , Chicago, Illinois, USA.
Tatyana GolovkinaDepartment of Microbiology, University of Chicago , Chicago, Illinois, USA.
University of Chicago · USThe University of Texas MD Anderson Cancer Center · US

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI KUNLE ODUNSI · 1985 to 2026
$122.1M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
Identification of the gene controlling murine retrovirus in YBR miceR21AI178056 · NIAID · UNIVERSITY OF CHICAGO · PI GOLOVKINA, TATYANA V · 2023 to 2024
$451k
NCATS NIH HHS UL1 TR000430NCI NIH HHS P30 CA014599NIAID NIH HHS R21 AI178056
6 · The paper itself

Abstract

Differential responses to viral infections are influenced by the genetic makeup of the host. Studies of resistance to retroviruses in human populations are complicated due to the inability to conduct proof-of-principle studies. Inbred mouse lines, which have a range of susceptible phenotypes to retroviruses, are an ideal tool to identify and characterize mechanisms of resistance and define their genetic underpinnings. YBR/Ei mice become infected with Mouse Mammary Tumor Virus, a mucosally transmitted murine retrovirus, but eliminate the virus from their pedigrees. Virus elimination correlates with a lack of virus-specific neonatal oral tolerance, which is a major mechanism for blocking the anti-virus response in susceptible mice. Virus control is unrelated to virus-neutralizing antibodies, cytotoxic CD8

Indexed as

RetroviridaeRetroviridae InfectionsAnimalsCD8-Positive T-LymphocytesDisease SusceptibilityHumansMiceMice, Inbred StrainsT-Lymphocytes, Cytotoxicgenetic mechanismimmune responseretroviruses

Identifiers

PMID37578238
PMCPMC10506465
OpenAlexW4385799212

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.