Evidence map›Paper›PMID 37578232›Full record

ArticleJournal of virology2023

Reverse genetics of parrot bornavirus 4 reveals a unique splicing of the glycoprotein gene that affects viral propagation.

Ryo Komorizono, Kan Fujino, Susanne Kessler, Solveig Runge, Takehiro Kanda, Masayuki Horie, Akiko Makino, Dennis Rubbenstroth, Keizo Tomonaga

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Ryo KomorizonoLaboratory of RNA Viruses, Department of Virus Research, Institute for Life and Medical Sciences (LiMe), Kyoto University , Kyoto, Japan.ORCID 0000-0002-7610-7985
Kan FujinoLaboratory of Microbiology, School of Veterinary Medicine, Azabu University , Kanagawa, Japan.
Susanne KesslerInstitute of Virology, Medical Centre - University of Freiburg , Freiburg, Germany.
Solveig RungeInstitute of Virology, Medical Centre - University of Freiburg , Freiburg, Germany.
Takehiro KandaLaboratory of RNA Viruses, Department of Virus Research, Institute for Life and Medical Sciences (LiMe), Kyoto University , Kyoto, Japan.
Masayuki HorieLaboratory of RNA Viruses, Department of Virus Research, Institute for Life and Medical Sciences (LiMe), Kyoto University , Kyoto, Japan.ORCID 0000-0003-4682-7698
Akiko MakinoLaboratory of RNA Viruses, Department of Virus Research, Institute for Life and Medical Sciences (LiMe), Kyoto University , Kyoto, Japan.
Dennis RubbenstrothInstitute of Virology, Medical Centre - University of Freiburg , Freiburg, Germany.
Keizo TomonagaLaboratory of RNA Viruses, Department of Virus Research, Institute for Life and Medical Sciences (LiMe), Kyoto University , Kyoto, Japan.ORCID 0000-0003-0405-7103
Kyoto University · JPUniversity of Freiburg · DEFriedrich-Loeffler-Institut · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viruses can utilize host splicing machinery to enable the expression of multiple genes from a limited-sized genome. Orthobornaviruses use alternative splicing to regulate the expression level of viral proteins and achieve efficient viral replication in the nucleus. Although more than 20 orthobornaviruses have been identified belonging to eight different viral species, virus-specific splicing has not been demonstrated. Here, we demonstrate that the glycoprotein (G) transcript of parrot bornavirus 4 (PaBV-4; species

Indexed as

Bird DiseasesBornaviridaeMononegavirales InfectionsParrotsAnimalsGlycoproteinsProtein IsoformsReverse GeneticsRNA, MessengerGlycoproteinsProtein IsoformsRNA, Messengeravian virusbornavirusproventricular dilatation diseasereverse genetic analysisRNA splicing

Identifiers

PMID37578232
PMCPMC10506466
OpenAlexW4385799029

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.