Evidence map›Paper›PMID 37578231›Full record

ArticleJournal of virology2023

Discontinuous L-binding motifs in the transactivation domain of the vesicular stomatitis virus P protein are required for terminal

Nirmala Gupta, Minako Ogino, Dean E Watkins, Tiffany Yu, Todd J Green, Tomoaki Ogino

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nirmala Gupta *Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.
Minako Ogino *Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.
Dean E WatkinsDepartment of Medical Microbiology and Immunology, College of Medicine and Life Sciences, University of Toledo , Toledo, Ohio, USA.
Tiffany YuDepartment of Medical Microbiology and Immunology, College of Medicine and Life Sciences, University of Toledo , Toledo, Ohio, USA.
Todd J GreenDepartment of Microbiology, School of Medicine, University of Alabama at Birmingham , Birmingham, Alabama, USA.ORCID 0000-0003-1158-4710
Tomoaki OginoDepartment of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.ORCID 0000-0002-4154-1781
University of Toledo Medical Center · USUniversity of Alabama at Birmingham · USUniversity School · US

Funding

mRNA synthesis and capping in nonsegmented negative strand RNA virusesR01AI093569 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI OGINO, TOMOAKI · 2012 to 2016
$1.8M
Dissecting catalytic and regulatory functions of nonsegmented negative strandRNA viral polymerasesR01AI146172 · NIAID · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI OGINO, TOMOAKI · 2019 to 2023
$1.8M
NIAID NIH HHS R01 AI093569NIAID NIH HHS R01 AI146172
6 · The paper itself

Abstract

The phospho- (P) protein, the co-factor of the RNA polymerase large (L) protein, of vesicular stomatitis virus (VSV, a prototype of nonsegmented negative-strand RNA viruses) plays pivotal roles in transcription and replication. However, the precise mechanism underlying the transcriptional transactivation by the P protein has remained elusive. Here, using an

Indexed as

Vesicular StomatitisAmino AcidsAnimalsRNA, MessengerRNA, ViralTranscriptional ActivationTranscription, GeneticVesicular stomatitis Indiana virusVesiculovirusVirus ReplicationAmino AcidsRNA, MessengerRNA, ViralL proteinMononegaviralesP proteinreplicationrhabdovirusRNA-dependent RNA polymerasetranscriptiontranscription factortranscription initiationvesicular stomatitis virus

Identifiers

PMID37578231
PMCPMC10506490
OpenAlexW4385798843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.