Evidence map›Paper›PMID 37577982›Full record

ArticleACS nano2023

Neutrophil-Mediated Delivery of Nanocrystal Drugs via Photoinduced Inflammation Enhances Cancer Therapy.

Yujie Su, Jin Gao, Xinyue Dong, Kraig A Wheeler, Zhenjia Wang

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 38 citations in OpenAlex.

  1. CAR-engineered neutrophils derived from induced pluripotent stem cells: a new frontier in cellular immunotherapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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  8. [Advancement in neutrophil-based drug delivery systems].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
  9. Harnessing myeloid cells in cancer.Molecular cancer · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yujie SuDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington 99202, United States.
Jin GaoDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington 99202, United States.ORCID 0000-0002-1437-229X
Xinyue DongDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington 99202, United States.
Kraig A WheelerDepartment of Chemistry, Whitworth University, Spokane, Washington 99251, United States.ORCID 0000-0001-6752-7542
Zhenjia WangDepartment of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington 99202, United States.ORCID 0000-0003-1155-1935
Washington State University Spokane · USWhitworth University · US

Funding

Neutrophil-mediated Drug DeliveryR01GM116823 · NIGMS · WASHINGTON STATE UNIVERSITY · PI WANG, ZHENJIA · 2016 to 2020
$1.8M
Active Drug Loading to Nanovesicles for Targeted Drug DeliveryR01EB027078 · NIBIB · WASHINGTON STATE UNIVERSITY · PI WANG, ZHENJIA · 2019 to 2023
$1.4M
NIBIB NIH HHS R01 EB027078NIGMS NIH HHS R01 GM116823
6 · The paper itself

Abstract

The efficient delivery of anticancer agents into tumor microenvironments is critical for the success of cancer therapies, but it is a prerequisite that drug carriers should overcome tumor vasculature and possess high drug contents. Here, we found that photoinduced inflammation response caused the migration of neutrophils into tumor microenvironments and neutrophils transported neutrophil-targeted nanoparticles (NPs) across the tumor blood barrier. The results showed that tumor delivery efficiencies of NPs were 5% ID/g, and they were independent of particle sizes (30-200 nm) and their doses (10

Indexed as

Antineoplastic AgentsNanoparticlesNeoplasmsAnimalsCell Line, TumorDrug CarriersInflammationMiceNeutrophilsPaclitaxelTumor MicroenvironmentAntineoplastic AgentsDrug CarriersPaclitaxelcarrier-free drug NPsdrug protein complexesneutrophil-mediated drug deliverypaclitaxel nanocrystalsparticle size/doseprotein-enhanced drug releasetumor delivery efficiency

Identifiers

PMID37577982
PMCPMC10480050
OpenAlexW4385798329

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.