ArticleJournal of the American Heart Association2023
Retinal Ischemic Perivascular Lesions in Individuals With Atrial Fibrillation.
Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 25 citations in OpenAlex.
- Distinct ocular microvascular alterations in Alzheimer's disease and cerebral small vessel disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Retinal ischemic perivascular lesions in cortical cerebral infarction: a comparison against controls.Eye (London, England) · 2026Article
- Retinal ischemic perivascular lesions in patients with pulmonary embolism: an OCT angiography study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Retinal Ischemic Perivascular Lesions Screen for Vision-Threatening Diabetic Retinopathy Visualized on Ultra-Widefield Fluorescein Angiography.Translational vision science & technology · 2026Article
- Retinal Ischemic Perivascular Lesions are Associated with Multifactorial Disease Burden and Severity of Diabetic Retinopathy.Ophthalmology science · 2026Article
- Brain-body interactions in systemic diseases: a survey from an imaging perspective.MedScience · 2026Review
- Association between coronary artery calcium scores and retinal ischemic perivascular lesions.International journal of retina and vitreous · 2026Article
- Simultaneous onset of visual dysfunction and cerebral infarction in a young patient with CADASIL: a case report.Frontiers in medicine · 2026Article
- Retinal Ischemic Perivascular Lesions Are Associated with Cardiovascular Diseases in Patients with Severe Carotid Artery Stenosis.Journal of clinical medicine · 2025Article
- Use of retinal ischemic perivascular lesions (RIPLS) as a biomarker for cardiovascular disease - a systematic review and meta-analysis.International journal of retina and vitreous · 2025Review
- Retinal ischemic perivascular lesion "a subclinical ischemic sign" in the fellow eye of patients with retinal vein occlusion.International ophthalmology · 2025Observational
- Retinal Imaging as a Window into Cardiovascular Health: Towards Harnessing Retinal Analytics for Precision Cardiovascular Medicine.Journal of cardiovascular development and disease · 2025Review
- Retinal Ischemic Perivascular Lesions (RIPLs) as Potential Biomarkers for Systemic Vascular Diseases: A Narrative Review of the Literature.Ophthalmology and therapy · 2025Review
- Retinal Ischemic Perivascular Lesions: An Exploratory Study of Their Potential as Biomarkers for Cardiovascular Disease.Journal of clinical medicine · 2025Article
- Assessment of retinal and choroidal microcirculatory alterations following radiofrequency catheter ablation in atrial fibrillation patients using swept-source optical coherence tomography angiography.Frontiers in cell and developmental biology · 2025Article
- Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop.Nature reviews. Cardiology · 2025Review
- Atrial fibrillation in Retinal Artery Occlusions.Cardiology and cardiovascular medicine · 2025Article
- The eye as a window to CVD: case series and literature review of retinal ischaemic perivascular lesion (RIPL).The British journal of cardiology · 2025Article
- Retinal Ischemic Perivascular Lesions Are Associated With Stroke in Individuals With Atrial Fibrillation.Journal of the American Heart Association · 2024Article
- Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
Background We previously demonstrated that retinal ischemic perivascular lesions (RIPLs), which are indicative of ischemia in the middle retina, may be a biomarker of ischemic cardiovascular disease. In this study, we sought to determine the relationship between RIPLs and atrial fibrillation, a common source of cardiac emboli. Methods and Results In this case-control study, we identified individuals between the ages of 50 and 90 years who had undergone macular spectral domain optical coherence tomography imaging. Individuals with atrial fibrillation were identified, and age- and sex-matched individuals from the same pool, but without a diagnosis of atrial fibrillation, were selected as controls. Spectral domain optical coherence tomography scans were reviewed by 3 independent and masked observers for presence of RIPLs. The relationship between RIPLs and atrial fibrillation was analyzed using multivariable logistic regression models. There were 106 and 91 subjects with and without atrial fibrillation, respectively. The percentage of subjects with RIPLs was higher in the atrial fibrillation group compared with the control group (57.5% versus 37.4%;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.