Evidence map›Paper›PMID 37577714›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to 2 Years Following COVID-19.

Michael J Peluso, Dylan Ryder, Robert Flavell, Yingbing Wang, Jelena Levi, Brian H LaFranchi, Tyler-Marie Deveau, Amanda M Buck, Sadie E Munter, Kofi A Asare and 24 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 46 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 2 institutions in 1 country.

Michael J PelusoDivision of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco, CA USA.
Dylan RyderDivision of Experimental Medicine, University of California San Francisco.
Robert FlavellDepartment of Radiology and Biomedical Imaging, University of California San Francisco.
Yingbing WangDepartment of Radiology and Biomedical Imaging, University of California San Francisco.
Jelena LeviCellSight Technologies, San Francisco, CA.
Brian H LaFranchiDivision of Experimental Medicine, University of California San Francisco.
Tyler-Marie DeveauDivision of Experimental Medicine, University of California San Francisco.
Amanda M BuckDivision of Experimental Medicine, University of California San Francisco.
Sadie E MunterDivision of Experimental Medicine, University of California San Francisco.
Kofi A AsareDivision of Experimental Medicine, University of California San Francisco.
Maya AslamDepartment of Radiology and Biomedical Imaging, University of California San Francisco.
Wally KochDepartment of Radiology and Biomedical Imaging, University of California San Francisco.
Gyula SzaboDepartment of Pathology, University of California San Francisco.
Rebecca HohDivision of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco, CA USA.
Monika DeswalDivision of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco, CA USA.
Antonio RodriguezDivision of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco, CA USA.
Melissa BuitragoDivision of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco, CA USA.
Viva TaiDivision of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco, CA USA.
Uttam ShresthaDepartment of Radiology and Biomedical Imaging, University of California San Francisco.
Scott LuDepartment of Epidemiology and Biostatistics, University of California San Francisco.
Sarah A GoldbergDepartment of Epidemiology and Biostatistics, University of California San Francisco.
Thomas DalhuisenDepartment of Epidemiology and Biostatistics, University of California San Francisco.
Matthew S DurstenfeldDivision of Cardiology, University of California San Francisco.
Priscilla Y HsueDivision of Cardiology, University of California San Francisco.
J Daniel KellyDepartment of Epidemiology and Biostatistics, University of California San Francisco.
Nitasha KumarDivision of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco, CA USA.
Jeffrey N MartinDepartment of Epidemiology and Biostatistics, University of California San Francisco.
Aruna GambirCellSight Technologies, San Francisco, CA.
Ma SomsoukDivision of Gastroenterology, University of California San Francisco.
Youngho SeoDepartment of Radiology and Biomedical Imaging, University of California San Francisco.
Steven G DeeksDivision of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, San Francisco, CA USA.
Zoltan G LaszikDepartment of Pathology, University of California San Francisco.
Henry F VanBrocklinDepartment of Radiology and Biomedical Imaging, University of California San Francisco.
Timothy J HenrichDivision of Experimental Medicine, University of California San Francisco.
University of California, San Francisco · USCellSight Technologies (United States) · US

Funding

Targeting Non Viral Markers of HIV PersistenceR01AI141003 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HENRICH, TIMOTHY JENSEN · 2018 to 2022
$4.9M
Evaluation of the Interplay between HIV and COVID-19 in a large urban safety-net HIV clinicR01AI158013 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GANDHI, MONICA, SPINELLI, MATTHEW A. · 2020 to 2023
$3.1M
Evaluating SARS-CoV-2 spike antigen-induced coagulopathy and neuroinflammation as mechanistic drivers of neurologic PASCR01NS136197 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Michael Joseph Peluso · 2024 to 2026
$2.0M
UCSF Career Development Program in Cardiopulmonary, Hematologic, and Immunologic Comorbidities of HIV (CHIC)K12HL143961 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HSUE, PRISCILLA Y., HUANG, LAURENCE · 2018 to 2022
$1.8M
Characterizing the virologic and immunologic signatures of HIV exceptional controlK23AI157875 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PELUSO, MICHAEL JOSEPH · 2021 to 2025
$927k
Persistent Functional Immune Defects in Treated HIV InfectionK24AI145806 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUNT, PETER W · 2020 to 2024
$921k
Understanding the epidemiology and natural history of unrecognized Ebola virus infectionK23AI146268 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KELLY, JOHN DANIEL · 2019 to 2022
$748k
NHLBI NIH HHS K12 HL143961NIAID NIH HHS K23 AI146268NIAID NIH HHS K23 AI157875NIAID NIH HHS K24 AI145806NIAID NIH HHS L30 AI126521NIAID NIH HHS L30 AI147159NIAID NIH HHS R01 AI141003NIAID NIH HHS R01 AI158013NINDS NIH HHS R01 NS136197
6 · The paper itself

Abstract

The etiologic mechanisms of post-acute medical morbidities and unexplained symptoms (Long COVID) following SARS-CoV-2 infection are incompletely understood. There is growing evidence that viral persistence and immune dysregulation may play a major role. We performed whole-body positron emission tomography (PET) imaging in a cohort of 24 participants at time points ranging from 27 to 910 days following acute SARS-CoV-2 infection using a novel radiopharmaceutical agent, [

Indexed as

COVID-19immune activationLong COVIDPET imagingpost-acute sequelae of SARS-CoV-2 (PASC)SARS-CoV-2viral persistence

Identifiers

PMID37577714
PMCPMC10418298
OpenAlexW4385459450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.