Evidence map›Paper›PMID 37577649›Full record

ArticlebioRxiv : the preprint server for biology2023

Monorhinal and Birhinal Odor Processing in Humans: an fMRI investigation.

Anupa Ekanayake, Qing Yang, Sangam Kanekar, Biyar Ahmed, Silas McCaslin, Deepak Kalra, Paul Eslinger, Prasanna Karunanayaka

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Anupa EkanayakeGrodno State Medical University, Grodno, Belarus.
Qing YangDepartment of Radiology, Penn State University College of Medicine, Hershey, PA, USA.
Sangam KanekarDepartment of Radiology, Penn State University College of Medicine, Hershey, PA, USA.
Biyar AhmedDepartment of Radiology, Penn State University College of Medicine, Hershey, PA, USA.
Silas McCaslinDepartment of Radiology, Penn State University College of Medicine, Hershey, PA, USA.
Deepak KalraDepartment of Neurology, Penn State University College of Medicine, Hershey, PA, USA.
Paul EslingerDepartment of Radiology, Penn State University College of Medicine, Hershey, PA, USA.
Prasanna KarunanayakaDepartment of Radiology, Penn State University College of Medicine, Hershey, PA, USA.
Penn State Milton S. Hershey Medical Center · USPennsylvania State University · USGrodno State Medical University · BY

Funding

Linking olfactory deficits to memory impairment and AD neurodegenerationR01AG070088 · NIA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KARUNANAYAKA, PRASANNA RASIKA, YANG, QING X · 2021 to 2025
$3.9M
Asymmetric neurodegeneration of central olfactory system in early-stage Parkinsons diseaseR01NS099630 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI WANG, JIANLI · 2017 to 2021
$2.4M
HFE SNP Effect on Alzheimer's Regional Brain SusceptibilityR21AG064486 · NIA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CONNOR, JAMES ROBERT, YANG, QING X · 2020 to 2021
$440k
NIA NIH HHS R01 AG070088NIA NIH HHS R21 AG064486NINDS NIH HHS R01 NS099630
6 · The paper itself

Abstract

The olfactory nerve, also known as cranial nerve I, is known to have exclusive ipsilateral projections to primary olfactory cortical structures. It is still unclear whether these projections also correspond to functional pathways of odor processing. In an olfactory functional magnetic resonance imaging (fMRI) study of twenty young healthy subjects with a normal sense of smell, we tested whether nostril specific stimulation with phenyl ethyl alcohol (PEA), a pure olfactory stimulant, asymmetrically activates primary or secondary olfactory-related brain structures such as primary olfactory cortex, entorhinal cortex, and orbitofrontal cortex. The results indicated that without a challenging olfactory task, passive (no sniffing) and active (with sniffing) nostril-specific PEA stimulation did not produce asymmetrical fMRI activation in olfactory cortical structures.

Indexed as

birhinalfMRImonorhinalolfactory system

Identifiers

PMID37577649
PMCPMC10418263
OpenAlexW4385520718

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.