Evidence map›Paper›PMID 37577635›Full record

ArticlebioRxiv : the preprint server for biology2024

A conserved odorant receptor underpins borneol-mediated repellency in culicine mosquitoes.

Yuri Vainer, Yinliang Wang, Robert M Huff, Dor Perets, Evyatar Sar-Shalom, Esther Yakir, Majid Ghaninia, Iliano V Coutinho-Abreu Gomes, Carlos Ruiz, Dhivya Rajamanickam and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Impact of elevated COScientific reports · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 4 countries.

Yuri VainerDepartment of Entomology, The Hebrew University of Jerusalem, Israel.
Yinliang WangDepartment of Entomology, The Hebrew University of Jerusalem, Israel.
Robert M HuffDepartment of Biology, Baylor University, USA.
Dor PeretsDepartment of Entomology, The Hebrew University of Jerusalem, Israel.
Evyatar Sar-ShalomDepartment of Entomology, The Hebrew University of Jerusalem, Israel.
Esther YakirDepartment of Entomology, The Hebrew University of Jerusalem, Israel.
Majid GhaniniaDepartment of Plant Protection Biology, Swedish University of Agricultural Sciences, Sweden.
Iliano V Coutinho-Abreu GomesDivision of Biological Sciences, University of California, USA.
Carlos RuizDepartment of Biology, University of Washington, USA.
Dhivya RajamanickamDepartment of Biology, Baylor University, USA.
A WarburgDepartment of Microbiology and Molecular Genetics, The Hebrew University of Jerusalem, Israel.
Omar S AkbariDivision of Biological Sciences, University of California, USA.ORCID 0000-0002-6853-9884
Philippos A PapathanosDepartment of Entomology, The Hebrew University of Jerusalem, Israel.
R IgnellDepartment of Plant Protection Biology, Swedish University of Agricultural Sciences, Sweden.
Jeffrey A RiffellDepartment of Biology, University of Washington, USA.
R Jason PittsDepartment of Biology, Baylor University, USA.ORCID 0000-0002-4863-9634
Jonathan D BohbotDepartment of Entomology, The Hebrew University of Jerusalem, Israel.ORCID 0000-0001-5204-6340
Hebrew University of Jerusalem · ILBaylor University · USSwedish University of Agricultural Sciences · SEUniversity of California San Diego · USUniversity of Washington · USNortheast Normal University · CN

Funding

The olfactory basis of locating nectar sugar sources in Aedes aegypti mosquitoesR01AI148300 · NIAID · UNIVERSITY OF WASHINGTON · PI Omar Sultan Akbari, Ronald Jason Pitts · 2021 to 2026
$4.1M
Olfactory modulation of color vision and behavior in mosquitoesR01AI175152 · NIAID · UNIVERSITY OF WASHINGTON · PI Omar Sultan Akbari, Jeffrey A Riffell · 2023 to 2026
$3.2M
NIAID NIH HHS R01 AI148300NIAID NIH HHS R01 AI175152
6 · The paper itself

Abstract

The use of essential oils derived from the camphor tree to repel mosquitoes is an ancient practice that originated in Southeast Asia and gradually spread to China and across Europe via the Maritime Silk Road. The olfactory mechanisms by which these oils elicit avoidance behavior are unclear. Here we show that plant bicyclic monoterpenoids and borneol specifically activate a neural pathway that originates in the orphan olfactory receptor neuron of the capitate peg sensillum in the maxillary palp, and projects to the mediodorsal glomerulus 3 in the antennal lobe. This neuron co-locates with two olfactory receptor neurons tuned to carbon dioxide and octenol that mediate human-host detection. We also confirm that borneol elicits repellency against human-seeking female mosquitoes. Understanding the functional role of the mosquito maxillary palp is essential to investigating olfactory signal integration and host-selection behavior.

Indexed as

borneolcamphormonoterpenoidsmosquitoesodorant receptorrepellent

Identifiers

PMID37577635
PMCPMC10418152
OpenAlexW4385520721

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.