Evidence map›Paper›PMID 37577621›Full record

ArticlebioRxiv : the preprint server for biology2023

A feedback control mechanism governs the synthesis of lipid-linked precursors of the bacterial cell wall.

Lindsey S Marmont, Anna K Orta, Robin A Corey, David Sychantha, Ana Fernández Galliano, Yancheng E Li, Becca W A Baileeves, Neil G Greene, Phillip J Stansfeld, William M Clemons and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Lindsey S MarmontDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.
Anna K OrtaDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA.
Robin A CoreySchool of Physiology, Pharmacology, and Neuroscience, University of Bristol, Bristol, UK.
David SychanthaM.G. DeGroote Institute for Infectious Disease Research, David Braley Centre for Antibiotic Discovery, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.
Ana Fernández GallianoM.G. DeGroote Institute for Infectious Disease Research, David Braley Centre for Antibiotic Discovery, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.
Yancheng E LiDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA.
Becca W A BaileevesSchool of Life Sciences and Department of Chemistry, University of Warwick, Warwick, UK.
Neil G GreeneDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.
Phillip J StansfeldSchool of Life Sciences and Department of Chemistry, University of Warwick, Warwick, UK.
William M ClemonsDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA.
Thomas G BernhardtDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.

Funding

Peptidoglycan Biogenesis in Escherichia ColiR01AI083365 · NIAID · HARVARD MEDICAL SCHOOL · PI Thomas G Bernhardt · 2010 to 2026
$8.3M
Mechanistic details of key integral-membrane enzymes for antimicrobial discoveryR01GM114611 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI William M. Clemons, Michio Kurosu · 2016 to 2026
$4.2M
Medical Research Council MR/S009213/1NIAID NIH HHS R01 AI083365NIGMS NIH HHS R01 GM114611Wellcome Trust
6 · The paper itself

Abstract

Many bacterial surface glycans such as the peptidoglycan (PG) cell wall, O-antigens, and capsules are built from monomeric units linked to a polyprenyl lipid carrier. How this limiting lipid carrier is effectively distributed among competing pathways has remained unclear for some time. Here, we describe the isolation and characterization of hyperactive variants of

Indexed as

bacteriologybiochemistryMajor: Biological SciencesMinor: Microbiologypeptidoglycantransferase

Identifiers

PMID37577621
PMCPMC10418202

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.