Evidence map›Paper›PMID 37577581›Full record

ArticlebioRxiv : the preprint server for biology2023

CCT and Cullin1 regulate the TORC1 pathway to promote dendritic arborization in health and disease.

Erin N Lottes, Feyza H Ciger, Shatabdi Bhattacharjee, Emily A Timmins-Wilde, Benoit Tete, Tommy Tran, Jais Matta, Atit A Patel, Daniel N Cox

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Erin N LottesNeuroscience Institute, Georgia State University, Atlanta, GA 30303, United States.
Feyza H CigerNeuroscience Institute, Georgia State University, Atlanta, GA 30303, United States.
Shatabdi BhattacharjeeNeuroscience Institute, Georgia State University, Atlanta, GA 30303, United States.
Emily A Timmins-WildeNeuroscience Institute, Georgia State University, Atlanta, GA 30303, United States.
Benoit TeteNeuroscience Institute, Georgia State University, Atlanta, GA 30303, United States.
Tommy TranNeuroscience Institute, Georgia State University, Atlanta, GA 30303, United States.
Jais MattaNeuroscience Institute, Georgia State University, Atlanta, GA 30303, United States.
Atit A PatelNeuroscience Institute, Georgia State University, Atlanta, GA 30303, United States.
Daniel N CoxNeuroscience Institute, Georgia State University, Atlanta, GA 30303, United States.
Georgia State University · US

Funding

Cytoskeletal mechanisms of dendrite arbor shape developmentR01NS086082 · NINDS · GEORGIA STATE UNIVERSITY · PI ASCOLI, GIORGIO A, COX, DANIEL N · 2013 to 2023
$3.1M
MARC Supplement at Georgia State University: Workforce Diversity Through Enhanced MentoringT34GM131939 · NIGMS · GEORGIA STATE UNIVERSITY · PI FRANTZ, KYLE J., GAUCHER, ERIC · 2019 to 2023
$1.7M
Uncovering the Roles of Chaperonin CCT in Neural Health and Disease.F31NS130970 · NINDS · GEORGIA STATE UNIVERSITY · PI LOTTES, ERIN · 2023 to 2023
$41k
NIGMS NIH HHS T34 GM131939NINDS NIH HHS F31 NS130970NINDS NIH HHS R01 NS086082
6 · The paper itself

Abstract

The development of cell-type-specific dendritic arbors is integral to the proper functioning of neurons within their circuit networks. In this study, we examine the regulatory relationship between the cytosolic chaperonin CCT, key insulin pathway genes, and an E3 ubiquitin ligase (Cullin1) in homeostatic dendritic development. CCT loss of function (LOF) results in dendritic hypotrophy in

Identifiers

PMID37577581
PMCPMC10418059
OpenAlexW4385481196

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.