Evidence map›Paper›PMID 37577569›Full record

ArticlebioRxiv : the preprint server for biology2023

Essential Gene Knockdowns Reveal Genetic Vulnerabilities and Antibiotic Sensitivities in

Ryan D Ward, Jennifer S Tran, Amy B Banta, Emily E Bacon, Warren E Rose, Jason M Peters

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ryan D WardPharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705.ORCID 0000-0001-9537-2461
Jennifer S TranPharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705.ORCID 0000-0003-4846-7163
Amy B BantaPharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705.ORCID 0000-0002-1843-5059
Emily E BaconPharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705.ORCID 0000-0001-8090-7689
Warren E RosePharmacy Practice Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705.ORCID 0000-0001-5012-5993
Jason M PetersPharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705.ORCID 0000-0003-2722-8382
University of Wisconsin–Madison · US

Funding

BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
Biotechnology Training ProgramT32GM135066 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI SCOTT M. COYLE, BRIAN G FOX · 2020 to 2026
$7.0M
CRISPR-based Functional Genomics in Pathogenic BacteriaK22AI137122 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI PETERS, JASON M. · 2018 to 2019
$269k
NIAID NIH HHS K22 AI137122NIGMS NIH HHS T32 GM007133NIGMS NIH HHS T32 GM008349NIGMS NIH HHS T32 GM135066
6 · The paper itself

Abstract

The emergence of multidrug-resistant Gram-negative bacteria underscores the need to define genetic vulnerabilities that can be therapeutically exploited. The Gram-negative pathogen,

Indexed as

antibiotic resistanceCRISPR interferencefunctional genomicssystems biology

Identifiers

PMID37577569
PMCPMC10418195
OpenAlexW4385551782

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.