Evidence map›Paper›PMID 37577461›Full record

ArticlebioRxiv : the preprint server for biology2023

Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition.

Dylan C Sarver, Jean Garcia-Diaz, Muzna Saqib, Ryan C Riddle, G William Wong

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dylan C SarverDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jean Garcia-DiazDepartment of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Muzna SaqibDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ryan C RiddleDepartment of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
G William WongDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins University · USUniversity of Maryland, Baltimore · US

Funding

CTRP and Metabolic ControlR01DK084171 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Guang William Wong · 2010 to 2026
$8.0M
Regulation of Osteoblast Metabolism by Lrp5R01DK099134 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI RIDDLE, RYAN C · 2013 to 2022
$3.4M
Bone-Adipose Interactions During Skeletal AnabolismR01AR077533 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI RIDDLE, RYAN C · 2021 to 2025
$1.7M
NIAMS NIH HHS R01 AR077533NIDDK NIH HHS R01 DK084171NIDDK NIH HHS R01 DK099134
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have identified a large number of candidate genes believed to affect longitudinal bone growth and bone mass. One of these candidate genes,

Indexed as

GHRgrowth hormonegrowth hormone insensitivityIGF-1Laron dwarfismskeletal dysplasia

Identifiers

PMID37577461
PMCPMC10418210
OpenAlexW4385549801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.