Evidence map›Paper›PMID 37577456›Full record

ArticlebioRxiv : the preprint server for biology2023

The Role of C-to-U RNA Editing in Human Biodiversity.

Melissa Van Norden, Zackary Falls, Sapan Mandloi, Brahm Segal, Bora Baysal, Ram Samudrala, Peter L Elkin

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Melissa Van NordenDepartment of Biomedical Informatics, University at Buffalo, Buffalo, NY, USA.
Zackary FallsDepartment of Biomedical Informatics, University at Buffalo, Buffalo, NY, USA.
Sapan MandloiDepartment of Biomedical Informatics, University at Buffalo, Buffalo, NY, USA.
Brahm SegalJacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.
Bora BaysalRoswell Park Cancer Center.
Ram SamudralaDepartment of Biomedical Informatics, University at Buffalo, Buffalo, NY, USA.
Peter L ElkinDepartment of Biomedical Informatics, University at Buffalo, Buffalo, NY, USA.
University at Buffalo, State University of New York · USRoswell Park Comprehensive Cancer Center · USUniversity of Southern Denmark · DK

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
National Library of Medicine Conference 2022T15LM012495 · NLM · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PETER L. ELKIN · 2017 to 2026
$4.3M
A translational bioinformatics approach to elucidate and mitigate polypharmacy induced adverse drug reactionsK01DA056690 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Zackary Michael Falls · 2022 to 2026
$1.0M
Buffalo Research Innovation in Genomic and Healthcare Technology (BRIGHT) Short-Term Training and EducationR25LM014213 · NLM · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PETER L. ELKIN, RAM SAMUDRALA · 2022 to 2026
$668k
Pain Medication Prescriptions and Misuse Following Treatment for Alcohol Use DisordersR21AA026954 · NIAAA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ELKIN, PETER L., LEONARD, KENNETH E · 2018 to 2019
$386k
NCATS NIH HHS UL1 TR001412NIAAA NIH HHS R21 AA026954NIDA NIH HHS K01 DA056690NLM NIH HHS R25 LM014213NLM NIH HHS T15 LM012495
6 · The paper itself

Abstract

Intra-organism biodiversity is thought to arise from epigenetic modification of our constituent genes and post-translational modifications after mRNA is translated into proteins. We have found that post-transcriptional modification, also known as RNA editing, is also responsible for a significant amount of our biodiversity, substantively expanding this story. The APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family RNA editing enzymes APOBEC3A and APOBEC3G catalyze the deamination of cytosines to uracils (C>U) in specific stem-loop structures.

Identifiers

PMID37577456
PMCPMC10418052
OpenAlexW4385459396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.