Evidence map›Paper›PMID 37577378›Full record

ArticleFrontiers in cellular and infection microbiology2023

Diarrheal-associated gut dysbiosis in cancer and inflammatory bowel disease patients is exacerbated by

Maria Kulecka, Natalia Zeber-Lubecka, Aneta Bałabas, Paweł Czarnowski, Katarzyna Bagińska, Maria Głowienka, Anna Kluska, Magdalena Piątkowska, Michalina Dąbrowska, Edyta Waker and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Maria KuleckaDepartment of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, Warsaw, Poland.
Natalia Zeber-LubeckaDepartment of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, Warsaw, Poland.
Aneta BałabasDepartment of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Paweł CzarnowskiDepartment of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Katarzyna BagińskaDepartment of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Maria GłowienkaDepartment of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Anna KluskaDepartment of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Magdalena PiątkowskaDepartment of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Michalina DąbrowskaDepartment of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Edyta WakerDepartment of Clinical Microbiology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Michał MikulaDepartment of Genetics, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Jerzy OstrowskiDepartment of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, Warsaw, Poland.
The Maria Sklodowska-Curie National Research Institute of Oncology · PLPostgraduate School of Molecular Medicine · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Low diversity gut dysbiosis can take different forms depending on the disease context. In this study, we used shotgun metagenomic sequencing and gas chromatography-mass spectrometry (GC-MS) to compared the metagenomic and metabolomic profiles of Results: The study cohort consisted of 138 case-mix cancer patients, 43 IBD patients, and 45 healthy control individuals. Thirty-three patients were also infected with Conclusion: Our data indicate that different external and internal factors drive comparable profiles of low diversity dysbiosis. While diarrheal-related low diversity dysbiosis may be a consequence of systemic cancer therapy, a similar phenotype is observed in cases of moderate to severe IBD, and in both cases, dysbiosis is exacerbated by incidence of CDI.

Indexed as

Clostridioides difficileClostridium InfectionsInflammatory Bowel DiseasesNeoplasmsBacteriaButyratesDiarrheaDysbiosisHumansButyratesCDIClostridioides difficilediarrheagut dysbiosisinflammatory bowel diseasemetabolitesmicrobiome

Identifiers

PMID37577378
PMCPMC10413277
OpenAlexW4385303078

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.