Evidence map›Paper›PMID 37577157›Full record

ArticleJAC-antimicrobial resistance2023

Activity of ceftolozane/tazobactam and imipenem/relebactam against clinical isolates of Enterobacterales and

James A Karlowsky, Sibylle H Lob, Stephen P Hawser, Nimmi Kothari, Fakhar Siddiqui, Irina Alekseeva, C Andrew DeRyke, Katherine Young, Mary R Motyl, Daniel F Sahm

Open access · goldAbstract read
In one paragraph

Article in JAC-antimicrobial resistance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Global epidemiology of carbapenem-resistantJAC-antimicrobial resistance · 2026
    Review
  3. Article
  4. In-vitro activity of the novel β-lactam/β-lactamase inhibitor combinations and cefiderocol against carbapenem-resistant Pseudomonas spp. clinical isolates collected in Switzerland in 2022.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  5. Novel Antibiotics for Gram-Negative Nosocomial Pneumonia.Antibiotics (Basel, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

James A KarlowskyIHMA, Schaumburg, IL 60173, USA.
Sibylle H LobIHMA, Schaumburg, IL 60173, USA.
Stephen P HawserIHMA, Monthey, Switzerland.
Nimmi KothariIHMA, Monthey, Switzerland.
Fakhar SiddiquiMerck & Co., Inc., Rahway, NJ, USA.
Irina AlekseevaMSD, Dubai, United Arab Emirates.
C Andrew DeRykeMerck & Co., Inc., Rahway, NJ, USA.
Katherine YoungMerck & Co., Inc., Rahway, NJ, USA.
Mary R MotylMerck & Co., Inc., Rahway, NJ, USA.
Daniel F SahmIHMA, Schaumburg, IL 60173, USA.
Merck & Co., Inc., Rahway, NJ, USA (United States) · USUniversity of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To evaluate the Methods: Participating clinical laboratories each collected up to 250 consecutive Gram-negative isolates per year from patients with bloodstream, intraabdominal, lower respiratory tract or urinary tract infections. MICs were determined by CLSI broth microdilution and interpreted using 2022 EUCAST breakpoints. β-Lactamase genes were identified in select β-lactam-non-susceptible isolate subsets. Results: Ninety-five percent of all Enterobacterales ( Conclusions: Recent clinical isolates of Enterobacterales and

Identifiers

PMID37577157
PMCPMC10416811
OpenAlexW4385778499

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.