ArticleSexual medicine2023
Association between inflammatory indexes and erectile dysfunction in U.S. adults: National Health and Nutrition Examination Survey 2001-2004.
Article in Sexual medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 17 citations in OpenAlex.
- Non-linear relationships between inflammatory indices and erectile dysfunction in a group of young men living with HIV.Basic and clinical andrology · 2026Article
- ZhongdaChat-ED: a medical large language model for personalized erectile dysfunction health consultation and professional clinical decision-making using retrieval-augmented generation.Asian journal of andrology · 2026Article
- Novel predictive factor for erectile dysfunction: systemic immune inflammation index.International journal of impotence research · 2025Article
- Association between the C-reactive protein-triglyceride glucose index and erectile dysfunction in US males: results from NHANES 2001-2004.International journal of impotence research · 2025Article
- Racial differences in hematologic profiles among men with erectile dysfunction: a cross-sectional analysis of NHANES 2001-2004.Translational andrology and urology · 2025Article
- Association between five novel anthropometric indices and erectile dysfunction in US adults from NHANES database.Scientific reports · 2025Article
- Association of the dietary index for gut microbiota and dietary inflammation index with metabolic dysfunction-associated steatotic liver disease and metabolic alcohol-associated liver disease.Frontiers in immunology · 2025Article
- Causal relationship between immune cells, inflammatory cytokines, metabolites, and erectile dysfunction: a two-sample Mendelian randomization study.Translational andrology and urology · 2024Article
- Association between the composite dietary antioxidant index and erectile dysfunction in US men: a cross-sectional study.Journal of health, population, and nutrition · 2024Article
- Association between inflammation indicators (MLR, NLR, SII, SIRI, and AISI) and erectile dysfunction in US adults: NHANES 2001-2004.Journal of health, population, and nutrition · 2024Article
- Association of METS-IR index with prevalence of erectile dysfunction in US adults: a cross-sectional study.International urology and nephrology · 2024Article
- Is erectile dysfunction associated with osteoarthritis and rheumatoid arthritis? Insights from a population-based study.Sexual medicine · 2024Article
- Association of systemic immune biomarkers with metabolic dysfunction-associated steatotic liver disease: a cross-sectional study of NHANES 2007-2018.Frontiers in nutrition · 2024Article
- Association between a novel inflammation-lipid composite marker CRP/HDL and erectile dysfunction: evidence from a large national cross-sectional study.Frontiers in endocrinology · 2024Article
- Association between polyunsaturated fatty acid intake and the prevalence of erectile dysfunction: A cross-sectional analysis of the NHANES 2001-2004.Lipids in health and disease · 2023Article
- Hemoglobin-to-Red Blood Cell Distribution Width Ratio and Erectile Dysfunction Among U.S. Adults: A Moderated Mediation Analysis of Body Roundness Index.American journal of men's healthArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The association of inflammatory biomarkers with erectile dysfunction (ED) is still largely unknown. Aim: The study sought to explore the association of inflammatory biomarkers with ED in U.S. adults. Methods: Participant data for this study were extracted from the National Health and Nutrition Examination Survey, and individuals that lacked information on clinical variables were excluded. Dose-response curve analysis was applied to explore the association of inflammatory biomarkers with ED prevalence. The confounders were adjusted for with weighted logistic regression analysis. We employed 1:1 propensity score matching to eliminate the effects of clinical variables to confirm the reliability of the results. Outcomes: ED prevalence was investigated with potential risk factors. Results: A total of 2331 men ≥20 years of age who participated in the National Health and Nutrition Examination Survey 2001-2004 were included in this study. Compared with individuals without ED, ED cohort displayed higher levels of neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, systemic immune-inflammatory index, and systemic inflammation response index. Dose-response curve analysis indicated ED prevalence increased with the increase of platelet-to-lymphocyte ratio, systemic immune-inflammatory index, and systemic inflammation response index. Weighed logistic regression analysis revealed neutrophil-to-lymphocyte ratio was positively associated with ED. The reliability of the results was confirmed by 1:1 propensity score matching reanalysis. Clinical Implications: Individuals with chronic inflammatory conditions should be alert for the development of ED. Strengths and Limitations: It is a large controlled study to investigate the relationship between inflammatory indexes and ED. However, it is a cross-sectional study and it lacks an accurate assessment of the degree of ED. Conclusion: Inflammatory biomarkers were associated with ED prevalence.
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