Evidence map›Paper›PMID 37577059›Full record

ReviewCurrent clinical microbiology reports2023

Conserved and Divergent Features of pH Sensing in Major Fungal Pathogens.

Shadab Farhadi Cheshmeh Morvari, Bethany L McCann, Elaine M Bignell

Open access · hybridAbstract readReview
In one paragraph

Review in Current clinical microbiology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Shadab Farhadi Cheshmeh Morvari *Manchester Fungal Infection Group, University of Manchester, Grafton Street, Manchester, M13 9NT UK.
Bethany L McCann *Medical Research Council Centre for Medical Mycology at The University of Exeter, Stocker Road, Exeter, EX4 4QD UK.
Elaine M BignellMedical Research Council Centre for Medical Mycology at The University of Exeter, Stocker Road, Exeter, EX4 4QD UK.ORCID 0000-0001-7748-1920
University of Exeter · GBUniversity of Manchester · GB

Funding

Medical Research Council G0501164Medical Research Council MR/S001824/2Medical Research Council MR/V033417/1
6 · The paper itself

Abstract

Purpose of Review: For human fungal pathogens, sensory perception of extracellular pH is essential for colonisation of mammalian tissues and immune evasion. The molecular complexes that perceive and transmit the fungal pH signal are membrane-proximal and essential for virulence and are therefore of interest as novel antifungal drug targets. Intriguingly, the sensory machinery has evolved divergently in different fungal pathogens, yet spatial co-ordination of cellular components is conserved. Recent Findings: The recent discovery of a novel pH sensor in the basidiomycete pathogen Summary: Our overview of current understanding highlights conserved and divergent mechanisms of the pH sensing machinery in model and pathogenic fungal species, as well as important unanswered questions that must be addressed to inform the future study of such sensing mechanisms and to devise therapeutic strategies for manipulating them.

Indexed as

AdaptationAspergillusCandidaCryptococcuspH signallingVirulence

Identifiers

PMID37577059
PMCPMC10421798
OpenAlexW4385344743

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.