Evidence map›Paper›PMID 37576932›Full record

ArticleFrontiers in behavioral neuroscience2023

The dendritic engram.

George Kastellakis, Simone Tasciotti, Ioanna Pandi, Panayiota Poirazi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in behavioral neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Reductionism in Engram Neuroscience.The European journal of neuroscience · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Memory engram stability and flexibility.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  13. Article
  14. Article
  15. Engram mechanisms of memory linking and identity.Nature reviews. Neuroscience · 2024
    Review
  16. Cellular computation and cognition.Frontiers in computational neuroscience · 2023
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

George Kastellakis *Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion, Greece.
Simone Tasciotti *Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion, Greece.
Ioanna Pandi *Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion, Greece.
Panayiota PoiraziInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion, Greece.
Foundation for Research and Technology Hellas · GRUniversity of Crete · GR

Funding

Experimental and modeling investigations into microcircuit, cellular and subcellular determinants of hippocampal ensemble recruitment to contextual representationsR01MH124867 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOSONCZY, ATTILA, POIRAZI, PANAYIOTA · 2021 to 2025
$3.4M
NIMH NIH HHS R01 MH124867
6 · The paper itself

Abstract

Accumulating evidence from a wide range of studies, including behavioral, cellular, molecular and computational findings, support a key role of dendrites in the encoding and recall of new memories. Dendrites can integrate synaptic inputs in non-linear ways, provide the substrate for local protein synthesis and facilitate the orchestration of signaling pathways that regulate local synaptic plasticity. These capabilities allow them to act as a second layer of computation within the neuron and serve as the fundamental unit of plasticity. As such, dendrites are integral parts of the memory engram, namely the physical representation of memories in the brain and are increasingly studied during learning tasks. Here, we review experimental and computational studies that support a novel, dendritic view of the memory engram that is centered on non-linear dendritic branches as elementary memory units. We highlight the potential implications of dendritic engrams for the learning and memory field and discuss future research directions.

Indexed as

dendritesengrammemorymodelingplasticity

Identifiers

PMID37576932
PMCPMC10412934
OpenAlexW4385305752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.