Evidence map›Paper›PMID 37576867›Full record

ReviewMaterials today. Bio2023

Microenvironment-targeted strategy steers advanced bone regeneration.

Shuyue Hao, Mingkai Wang, Zhifeng Yin, Yingying Jing, Long Bai, Jiacan Su

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuyue HaoInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Mingkai WangInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Zhifeng YinDepartment of Orthopedics, Shanghai Zhongye Hospital, Shanghai, 201941, China.
Yingying JingInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Long BaiInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.
Jiacan SuInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment of large bone defects represents a great challenge in orthopedic and craniomaxillofacial surgery. Traditional strategies in bone tissue engineering have focused primarily on mimicking the extracellular matrix (ECM) of bone in terms of structure and composition. However, the synergistic effects of other cues from the microenvironment during bone regeneration are often neglected. The bone microenvironment is a sophisticated system that includes physiological (e.g., neighboring cells such as macrophages), chemical (e.g., oxygen, pH), and physical factors (e.g., mechanics, acoustics) that dynamically interact with each other. Microenvironment-targeted strategies are increasingly recognized as crucial for successful bone regeneration and offer promising solutions for advancing bone tissue engineering. This review provides a comprehensive overview of current microenvironment-targeted strategies and challenges for bone regeneration and further outlines prospective directions of the approaches in construction of bone organoids.

Indexed as

BiomaterialsBone regenerationChemical microenvironmentPhysical microenvironmentPhysiological microenvironment

Identifiers

PMID37576867
PMCPMC10413201

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.