ArticleFrontiers in bioinformatics2023
Current successes and remaining challenges in protein function prediction.
Article in Frontiers in bioinformatics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 23 citations in OpenAlex.
- GPCR-GO: Relation-aware graph learning for predicting Gene Ontology terms of G protein-coupled receptors.PLoS computational biology · 2026Article
- Predicting functions of uncharacterized gene products from microbial communities.Nature biotechnology · 2026Article
- Constructing gene co-functional and co-regulatory networks from public transcriptomes using condition-specific ensemble co-expression.Nature communications · 2026Article
- Evaluating network-based algorithms for protein function prediction using plant protein-protein interaction networks.BMC plant biology · 2026Article
- Exploring antibiotic resistance in diverse homologs of the dihydrofolate reductase protein family through broad mutational scanning.Science advances · 2025Article
- Investigating the determinants of performance in machine learning for protein fitness prediction.Protein science : a publication of the Protein Society · 2025Article
- Common Variable Immunodeficiency Clinical Manifestations Are Shaped by Presence and Type of Heterozygous NFKB1 Variants.The journal of allergy and clinical immunology. In practice · 2025Article
- Deciphering the proteome ofComputational and structural biotechnology journal · 2025Article
- A Survey of Biological Function Prediction Methods with Focus on Natural Language Processing (NLP) and Large Language Models (LLM).Methods in molecular biology (Clifton, N.J.) · 2025Article
- The need for adaptability in detection, characterization, and attribution of biosecurity threats.Nature communications · 2024Review
- Heterogeneous network approaches to protein pathway prediction.Computational and structural biotechnology journal · 2024Review
- Protein subcellular localization prediction tools.Computational and structural biotechnology journal · 2024Review
- DeepSS2GO: protein function prediction from secondary structure.Briefings in bioinformatics · 2024Article
- SEN1990 is a predicted winged helix-turn-helix protein involved in the pathogenicity ofFrontiers in microbiology · 2023Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, improvements in protein function prediction methods have led to increased success in annotating protein sequences. However, the functions of over 30% of protein-coding genes remain unknown for many sequenced genomes. Protein functions vary widely, from catalyzing chemical reactions to binding DNA or RNA or forming structures in the cell, and some types of functions are challenging to predict due to the physical features associated with those functions. Other complications in understanding protein functions arise due to the fact that many proteins have more than one function or very small differences in sequence or structure that correspond to different functions. We will discuss some of the recent developments in predicting protein functions and some of the remaining challenges.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.