Evidence map›Paper›PMID 37576491›Full record

ArticleCurrent research in neurobiology2023

Propranolol reduces the accumulation of cytotoxic aggregates in C9orf72-ALS/FTD

Mira Seidel, Sandeep Rajkumar, Christina Steffke, Vivien Noeth, Shreya Agarwal, Kevin Roger, Joanna Lipecka, Albert Ludolph, Chiara Ida Guerrera, Tobias Boeckers and 1 more

Open access · goldAbstract read
In one paragraph

Article in Current research in neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Targeting GeneInternational journal of molecular sciences · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Mira SeidelInstitute of Anatomy and Cell Biology, Ulm University School of Medicine, Ulm, Germany.
Sandeep RajkumarInstitute of Anatomy and Cell Biology, Ulm University School of Medicine, Ulm, Germany.
Christina SteffkeInstitute of Anatomy and Cell Biology, Ulm University School of Medicine, Ulm, Germany.
Vivien NoethInstitute of Anatomy and Cell Biology, Ulm University School of Medicine, Ulm, Germany.
Shreya AgarwalInstitute of Anatomy and Cell Biology, Ulm University School of Medicine, Ulm, Germany.
Kevin RogerProteomics Platform Necker, Université Paris Cité - Structure Fédérative de Recherche Necker, INSERM US24/CNRS UAR3633, Paris, France.
Joanna LipeckaProteomics Platform Necker, Université Paris Cité - Structure Fédérative de Recherche Necker, INSERM US24/CNRS UAR3633, Paris, France.
Albert LudolphDepartment of Neurology, Ulm University School of Medicine, Ulm, Germany.
Chiara Ida GuerreraProteomics Platform Necker, Université Paris Cité - Structure Fédérative de Recherche Necker, INSERM US24/CNRS UAR3633, Paris, France.
Tobias BoeckersInstitute of Anatomy and Cell Biology, Ulm University School of Medicine, Ulm, Germany.
Alberto CataneseInstitute of Anatomy and Cell Biology, Ulm University School of Medicine, Ulm, Germany.
Universität Ulm · DECentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the

Indexed as

AggregatesALSAutophagyC9orf72FTDhiPSCLysosomesNeurodegenerationNeuronsPoly(GA)

Identifiers

PMID37576491
PMCPMC10412779
OpenAlexW4385389357

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.