Evidence map›Paper›PMID 37576435›Full record

ArticleSensors and actuators. B, Chemical2018

An ultra low-cost smartphone device for in-situ monitoring of acute organophosphorus poisoning for agricultural workers.

Yu-Chung Chang, Xiaoxiao Ge, Li-Ju Wang, Stephen Sauchi Lee, Michael H Paulsen, Qaiser M Khan, Zafar M Khalid, Javed A Bhalli, Usman Waheed, Christopher D Simpson and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors and actuators. B, Chemical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yu-Chung ChangSchool of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA.
Xiaoxiao GeSchool of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA.
Li-Ju WangSchool of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA.
Stephen Sauchi LeeDepartment of Statistical Science, University of Idaho, Moscow, ID 83844, USA.
Michael H PaulsenDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA.
Qaiser M KhanNational Institute for Biotechnology and Genetic Engineering, P.O. Box 577, Jhang Road, Faisalabad, Pakistan.
Zafar M KhalidNational Institute for Biotechnology and Genetic Engineering, P.O. Box 577, Jhang Road, Faisalabad, Pakistan.
Javed A BhalliNational Institute for Biotechnology and Genetic Engineering, P.O. Box 577, Jhang Road, Faisalabad, Pakistan.
Usman WaheedNational Institute for Biotechnology and Genetic Engineering, P.O. Box 577, Jhang Road, Faisalabad, Pakistan.
Christopher D SimpsonDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA.
Dan DuSchool of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA.
Lei LiSchool of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA.
Yuehe LinSchool of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA.

Funding

NIOSH CDC HHS R21 OH010768NIOSH CDC HHS U54 OH007544
6 · The paper itself

Abstract

In this work, we present an ultra-low-cost smartphone device for in situ quantification of OP poisoning severity. The performance of the lens-less smartphone spectrum apparatus (LeSSA) is evaluated using standard human Interleukin-6 (IL-6) immunoassay kits. Upon dose-response curve fitting, LeSSA demonstrates an accuracy of 99.5%. The limit of detection (LOD) of LeSSA was evaluated through comparison of 6.4 pg/ml with standard laboratory grade UV-vis spectrophotometer at 5.5 pg/ml. Evaluating the capacity of LeSSA in spike solution by combining plasma cholinesterase (PChE) and human plasma shows consistency at agreement of 97.6% between LeSSA and the laboratory instrument. For application demonstration, the activity of PChE for 24 agricultural workers' plasma samples was measured with LeSSA, showing exceptional agreement (r2 = 0.92) with the laboratory instrument reference. In addition to near laboratory grade accuracy, the total manufacturing cost of LeSSA is only $20 USD highlighting it's affordability. With LeSSA, clinicians can evaluate OP poisoning severity without the need to transport patient samples to facilities at far distances. Utilizing LeSSA, immediate results can be used for administration of appropriate treatment.

Indexed as

Mobile deviceOrganophosphorus poisoningPoint-of-care diagnostics

Identifiers

PMID37576435
PMCPMC10422983

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.