Evidence map›Paper›PMID 37576301›Full record

ArticleHeliyon2023

Elevated tissue transglutaminase levels in aqueous humor of congenital cataractous eyes with long axial length.

Tianke Yang, Xiyue Zhou, Hongzhe Li, Fan Fan, Jianing Yang, Xiaolei Lin, Xin Liu, Yi Luo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 70% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Tianke YangDepartment of Ophthalmology, Eye Institute, Eye & ENT Hospital, Fudan University, Shanghai, China.
Xiyue ZhouDepartment of Ophthalmology, Eye Institute, Eye & ENT Hospital, Fudan University, Shanghai, China.
Hongzhe LiDepartment of Ophthalmology, Eye Institute, Eye & ENT Hospital, Fudan University, Shanghai, China.
Fan FanDepartment of Ophthalmology, Eye Institute, Eye & ENT Hospital, Fudan University, Shanghai, China.
Jianing YangDepartment of Ophthalmology, Eye Institute, Eye & ENT Hospital, Fudan University, Shanghai, China.
Xiaolei LinDepartment of Ophthalmology, Eye Institute, Eye & ENT Hospital, Fudan University, Shanghai, China.
Xin LiuDepartment of Ophthalmology, Eye Institute, Eye & ENT Hospital, Fudan University, Shanghai, China.
Yi LuoDepartment of Ophthalmology, Eye Institute, Eye & ENT Hospital, Fudan University, Shanghai, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNEye & ENT Hospital of Fudan University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the distribution of axial length (AL) and posterior staphyloma (PS) in congenital cataract (CC) patients. The correlation between AL and the concentration of tissue transglutaminase (TGM2) in the aqueous humor (AH) of cataractous eyes was also evaluated. Methods: Cross-sectional data were collected from 499 children with CC who underwent phacoemulsification, anterior vitrectomy, and IOL implantation. AL measured by IOLMaster or A-scan ultrasonography and the presence of PS examined by B-scan ultrasonography were recorded. TGM2 levels in AH of 15 CC patients with normal axial length (NAL) and 15 CC patients with PS or long axial length (LAL) were measured by enzyme-linked immunosorbent assay. Results: The presence of PS in congenital cataractous eyes was 11.02%, and the presence of PS + LAL in congenital cataractous eyes was 29.06%. The AH levels of TGM2 in the cataractous group with NAL were lower than those in the cataractous group with PS or LAL ( Conclusions: This study begins to lay the groundwork for investigating the characteristics of PS and LAL in patients with CC. Furthermore, AL was positively correlated with AH levels of TGM2.

Indexed as

Aqueous humorAxial lengthCongenital cataractPosterior staphylomaTissue transglutaminase

Identifiers

PMID37576301
PMCPMC10412761
OpenAlexW4385267017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.