Evidence map›Paper›PMID 37575807›Full record

ArticleCureus2023

A Retrospective Analysis of Vitamin D Levels in Hospitalized COVID-19 Patients With Suspected Pulmonary Embolism.

Shaun V Charkowick, Constantine N Logothetis, Katherine Tsay, Aryanna Jordan, Catherine Hanna, Sherry Zhang, Emily Coughlin, Thomas A Weppelmann, Rahul Mhaskar, Asa Oxner

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Shaun V CharkowickCollege of Medicine, University of South Florida Health Morsani College of Medicine, Tampa, USA.
Constantine N LogothetisDepartment of Internal Medicine, University of South Florida Health Morsani College of Medicine, Tampa, USA.
Katherine TsayCollege of Medicine, University of South Florida Health Morsani College of Medicine, Tampa, USA.
Aryanna JordanDepartment of Internal Medicine, University of South Florida Health Morsani College of Medicine, Tampa, USA.
Catherine HannaCollege of Medicine, University of South Florida Health Morsani College of Medicine, Tampa, USA.
Sherry ZhangCollege of Medicine, University of South Florida Health Morsani College of Medicine, Tampa, USA.
Emily CoughlinCollege of Medicine, University of South Florida Health Morsani College of Medicine, Tampa, USA.
Thomas A WeppelmannDepartment of Ophthalmology, University of South Florida Health Morsani College of Medicine, Tampa, USA.
Rahul MhaskarDepartment of Internal Medicine, University of South Florida Health Morsani College of Medicine, Tampa, USA.
Asa OxnerDepartment of Internal Medicine, University of South Florida Health Morsani College of Medicine, Tampa, USA.
University of South Florida · USKaiser Permanente Oakland Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction Despite using anti-coagulation therapy in hospitalized coronavirus disease 2019 (COVID-19) patients, they have high rates of pulmonary embolism (PE) and deep vein thrombosis (DVT). The main objective of this study was to evaluate the association between vitamin D deficiency and thrombotic events (defined as the occurrence of a new PE or DVT) in hospitalized COVID-19 patients. Materials and Methods This was a retrospective, cross-sectional study of 208 hospitalized COVID-19 patients who received a computed tomographic pulmonary angiography (CTPA) based on clinical suspicion of PE between January 1, 2020, and February 5, 2021. A <20 ng/mL serum vitamin D level was used to categorize vitamin D deficiency. Nonparametric tests and multivariate binary logistic regression were used to evaluate the association between serum vitamin D levels and clinical outcomes. Results The mean vitamin D level was 26.7±13.0 ng/mL (n=208), and approximately one-third of patients were vitamin D deficient (n=68, 32.7%). No association was found between vitamin D deficiency and the occurrence of thrombotic events. The incidence of PE was 19.1% in vitamin D deficient patients compared to 11.4% in vitamin D sufficient patients (p=0.13). Vitamin D deficiency was positively associated with ICU admission (OR 3.047, 95%CI 1.57-5.91, p=0.001) and mortality (OR 3.76, 95%CI 1.29-11.01, p=0.016). Conclusions This study found no association between vitamin D deficiency and the occurrence of a new PE or DVT in hospitalized COVID-19 patients. Patients with vitamin D deficiency were more likely to be admitted to the ICU and had increased overall mortality.

Indexed as

american thoracic societyarea deprivation indexcovid-19deep vein thrombosisicupulmonary embolismvitamin d

Identifiers

PMID37575807
PMCPMC10422855
OpenAlexW4384201053

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.