Evidence map›Paper›PMID 37575479›Full record

ArticleFunction (Oxford, England)2023

Urine-based Detection of Congenital Portosystemic Shunt in C57BL/6 Mice.

Beng San Yeoh, Rachel M Golonka, Piu Saha, Mrunmayee R Kandalgaonkar, Yuan Tian, Islam Osman, Andrew D Patterson, Andrew T Gewirtz, Bina Joe, Matam Vijay-Kumar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Function (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Elevated circulating bile acids driven erythrocyte osmotic resistance marks hepatobiliary disease.American journal of physiology. Gastrointestinal and liver physiology · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Beng San YeohDepartment of Physiology and Pharmacology, The University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Rachel M GolonkaDepartment of Physiology and Pharmacology, The University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Piu SahaDepartment of Physiology and Pharmacology, The University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Mrunmayee R KandalgaonkarDepartment of Physiology and Pharmacology, The University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Yuan TianDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Islam OsmanDepartment of Physiology and Pharmacology, The University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Andrew D PattersonDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0003-2073-0070
Andrew T GewirtzCenter for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
Bina JoeDepartment of Physiology and Pharmacology, The University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Matam Vijay-KumarDepartment of Physiology and Pharmacology, The University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.ORCID 0000-0002-8732-0167
University of Toledo · USPennsylvania State University · USGeorgia State University · US

Funding

Interplay between Dietary Fiber and Gut Microbiota in Hepatocellular CarcinomaR01CA219144 · NCI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI VIJAY-KUMAR, MATAM · 2017 to 2021
$1.6M
R01: FXR and the Gut Microbiome as Modulators of Non-Alcoholic Fatty Liver DiseaseU01DK119702 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW · 2019 to 2023
$1.5M
YAP1, neointima formation, and blood pressure regulationR00HL153896 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI OSMAN, ISLAM · 2023 to 2025
$747k
Targeting Gut Microbiota Metabolites to Prevent Liver CancerF31CA260842 · NCI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI GOLONKA, RACHEL M. · 2022 to 2023
$54k
NCI NIH HHS F31 CA260842NCI NIH HHS R01 CA219144NHLBI NIH HHS R00 HL153896NIDDK NIH HHS U01 DK119702
6 · The paper itself

Abstract

Sporadic occurrence of congenital portosystemic shunt (PSS) at a rate of ∼1 out of 10 among C57BL/6 J mice, which are widely used in biomedical research, results in aberrancies in serologic, metabolic, and physiologic parameters. Therefore, mice with PSS should be identified as outliers in research. Accordingly, we sought methods to, reliably and efficiently, identify PSS mice. Serum total bile acids ≥ 40 µm is a

Indexed as

Portasystemic Shunt, Transjugular IntrahepaticVascular MalformationsAnimalsBiomarkersMiceMice, Inbred C57BLPortal SystemBiomarkersbile acidsenterohepatic circulationiron chelationKrebs cycleliver shuntpH

Identifiers

PMID37575479
PMCPMC10413929
OpenAlexW4385377483

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.