Evidence map›Paper›PMID 37575332›Full record

ArticleFrontiers in nutrition2023

Effectiveness of locally produced ready to use supplementary food on hemoglobin, anthropometrics, and plasma micronutrients concentrations of 6 to 23 months age children: a non-randomized community-based trial from Pakistan.

Aslam Khan, Zia Ul-Haq, Sheraz Fazid, Sadia Fatima, Nawshad Muhammad, Jawad Ahmed, Salim Manoharadas, Sher Zaman Safi, Ijaz Habib, Cecilia Garzon and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Aslam KhanInstitute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.
Zia Ul-HaqInstitute of Public Health and Social Sciences, Khyber Medical University, Peshawar, Pakistan.
Sheraz FazidInstitute of Public Health and Social Sciences, Khyber Medical University, Peshawar, Pakistan.
Sadia FatimaInstitute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.
Nawshad MuhammadInstitute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.
Jawad AhmedInstitute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan.
Salim ManoharadasDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Sher Zaman SafiFaculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom, Malaysia.
Ijaz HabibWorld Food Programme, Peshawar, Pakistan.
Cecilia GarzonWorld Food Programme, Islamabad, Pakistan.
Yasir IhteshamWorld Food Programme, Islamabad, Pakistan.
Fareeda ZahidWorld Food Programme, Peshawar, Pakistan.
Fazal DadWorld Food Programme, Peshawar, Pakistan.
Tanimoune MahamadouWorld Food Programme, Islamabad, Pakistan.
Nicola M LoweUCLan Research Centre for Global Development, University of Central Lancashire, Preston, United Kingdom.
Khyber Medical University · PKKing Saud University · SAMahsa University · MYUniversity of Central Lancashire · GBUniversity of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Micronutrient deficiencies including vitamin A, vitamin D, and zinc are highly prevalent in children below 5 years of age in low and -middle-income countries. We aimed to evaluate the effectiveness of ready-to-use Lipid-based Nutrient Supplement-Medium Quantity (LNS-MQ) local name "Wawa-mum" on plasma micronutrient status, hemoglobin concentration and anthropometric measurements. Methods: A community-based non-randomized trial was conducted in the Kurram district of Khyber Pakhtunkhwa from January 2018 to June 2019. A total of 110 children aged 6 to 23 months old were recruited and allocated to the intervention and control arm of the study. A total of 57 children in the intervention arm received a daily ration of 50 g of Wawa-mum, for one year. To assess the impact of the intervention on primary outcome measures, i.e., serum vitamin A, D concentration, plasma zinc, and hemoglobin concentration. Blood samples were collected at baseline and after one year following the intervention. The vitamins concentration in serum were assessed using Enzyme-Linked Immunosorbent Assay (ELISA) and plasma zinc by atomic absorption spectrometry. The hemoglobin concentration was measured by an automated hematology analyzer. A 24-h dietary recall interview was used to assess the nutrient intake adequacy. Multivariate Linear regression models were used to analyze the outcomes while controlling for potential confounders. Results: In the intervention arm, children had on average 6.2 μg/dL (95% CI 3.0-9.3, value of Conclusion: Wawa-mum (LNS-MQ) is an effective intervention to improve the micronutrient status, hemoglobin concentration, and growth parameters in 6 to 23 months children, which can be scaled up in the existing health system to address the alarming rates of under nutrition in Pakistan and other developing countries. Clinical trial registration: https://doi.org/10.1186/ISRCTN94319790, ISRCTN94319790.

Indexed as

anemiagrowthmalnutritionSQ-LNSstuntingvitamin Avitamin Dzinc

Identifiers

PMID37575332
PMCPMC10415027
OpenAlexW4385324183

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.