Evidence map›Paper›PMID 37575256›Full record

ArticleFrontiers in immunology2023

Chitinase-3-like 1 regulates T

Miranda L Curtiss, Alexander F Rosenberg, Christopher D Scharer, Betty Mousseau, Natalia A Ballesteros Benavides, John E Bradley, Beatriz León, Chad Steele, Troy D Randall, Frances E Lund

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Miranda L CurtissDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care, University of Alabama Birmingham (UAB), Birmingham, AL, United States.
Alexander F RosenbergDepartment of Microbiology, University of Alabama Birmingham (UAB), Birmingham, AL, United States.
Christopher D ScharerDepartment of Microbiology and Immunology, Emory University, Atlanta, GA, United States.
Betty MousseauDepartment of Microbiology, University of Alabama Birmingham (UAB), Birmingham, AL, United States.
Natalia A Ballesteros BenavidesDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care, University of Alabama Birmingham (UAB), Birmingham, AL, United States.
John E BradleyDepartment of Medicine, Division of Rheumatology, University of Alabama Birmingham (UAB), Birmingham, AL, United States.
Beatriz LeónDepartment of Microbiology, University of Alabama Birmingham (UAB), Birmingham, AL, United States.
Chad SteeleDepartment of Microbiology and Immunology, Tulane University, New Orleans, LA, United States.
Troy D RandallDepartment of Medicine, Division of Rheumatology, University of Alabama Birmingham (UAB), Birmingham, AL, United States.
Frances E LundDepartment of Microbiology, University of Alabama Birmingham (UAB), Birmingham, AL, United States.
University of Alabama at Birmingham · USBirmingham VA Medical Center · USEmory University · USTulane University · US

Funding

Immunopathogenesis in fungal asthmaR01HL122426 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Chad Steele · 2015 to 2026
$5.1M
Training Program in Lung Biology and Translational MedicineT32HL105346 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GAGGAR, AMIT · 2010 to 2025
$5.0M
Regulation of T cell responses to allergens and environmental microbesR01AI116584 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LUND, FRANCES E. · 2015 to 2024
$4.1M
Protective functions of influenza-specific lung-resident memory B cellsR01AI153413 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI RANDALL, TROY D · 2020 to 2025
$3.5M
Controlling Th2 immunity by tuning CXCL13 dependent DC migration in lymph nodesR01AI104725 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LUND, FRANCES E. · 2013 to 2017
$1.8M
NHLBI NIH HHS R01 HL122426NHLBI NIH HHS T32 HL105346NIAID NIH HHS R01 AI104725NIAID NIH HHS R01 AI116584NIAID NIH HHS R01 AI153413
6 · The paper itself

Abstract

Introduction: Data from patient cohorts and mouse models of atopic dermatitis, food allergy and asthma strongly support a role for chitinase-3-like-1 protein (CHI3L1) in allergic disease. Methods: To address whether Chi3l1 also contributes to T Results: As anticipated, we observed impaired T Discussion: These results suggest that

Indexed as

ChitinasesHelminthiasisHelminthsAnimalsChitinase-3-Like Protein 1Immunoglobulin EInterleukin-4MiceT-Lymphocytes, Helper-InducerChil1 protein, mouseChitinase-3-Like Protein 1ChitinasesImmunoglobulin EInterleukin-4entericgerminal centergerminal center (GC) B cellshelminthIgE (immunoglobulin E)IL-4T follicular helper (T cell FHT helper 2 (Th2) cells

Identifiers

PMID37575256
PMCPMC10415220
OpenAlexW4385294366

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.