Evidence map›Paper›PMID 37575192›Full record

ArticleiScience2023

Fetal metabolic adaptations to cardiovascular stress in twin-twin transfusion syndrome.

Jacqueline G Parchem, Huihui Fan, Lovepreet K Mann, Qiuying Chen, Jong H Won, Steven S Gross, Zhongming Zhao, Heinrich Taegtmeyer, Ramesha Papanna

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jacqueline G ParchemDepartment of Obstetrics, Gynecology & Reproductive Sciences, Division of Maternal-Fetal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Huihui FanCenter for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Lovepreet K MannDepartment of Obstetrics, Gynecology & Reproductive Sciences, Division of Maternal-Fetal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Qiuying ChenDepartment of Pharmacology, Weill Cornell Medicine, New York, NY, USA.
Jong H WonDepartment of Obstetrics, Gynecology & Reproductive Sciences, Division of Maternal-Fetal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Steven S GrossDepartment of Pharmacology, Weill Cornell Medicine, New York, NY, USA.
Zhongming ZhaoCenter for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Heinrich TaegtmeyerDepartment of Internal Medicine, Division of Cardiology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Ramesha PapannaDepartment of Obstetrics, Gynecology & Reproductive Sciences, Division of Maternal-Fetal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
The University of Texas Health Science Center at Houston · USCornell University · USMemorial Hermann · US

Funding

Metabolic remodeling of skeletal muscle in mitochondrial myopathiesR01AR076029 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, QIUYING, D'AURELIO, MARILENA · 2020 to 2024
$2.7M
Modulation of intermediate metabolism, a new therapeutic approach for mitochondrial encephalomyopathiesR21NS118233 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, QIUYING, D'AURELIO, MARILENA · 2021 to 2021
$466k
NIAMS NIH HHS R01 AR076029NINDS NIH HHS R21 NS118233
6 · The paper itself

Abstract

Monochorionic-diamniotic twin pregnancies are susceptible to unique complications arising from a single placenta shared by two fetuses. Twin-twin transfusion syndrome (TTTS) is a constellation of disturbances caused by unequal blood flow within the shared placenta giving rise to a major hemodynamic imbalance between the twins. Here, we applied TTTS as a model to uncover fetal metabolic adaptations to cardiovascular stress. We compared untargeted metabolomic analyses of amniotic fluid samples from severe TTTS cases vs. singleton controls. Amniotic fluid metabolites demonstrated alterations in fatty acid, glucose, and steroid hormone metabolism in TTTS. Among TTTS cases, unsupervised principal component analysis revealed two distinct clusters of disease defined by levels of glucose metabolites, amino acids, urea, and redox status. Our results suggest that the human fetal heart can adapt to hemodynamic stress by modulating its glucose metabolism and identify potential differences in the ability of individual fetuses to respond to cardiovascular stress.

Indexed as

Biology of human developmentCardiovascular medicineDevelopmental anatomyHealth sciences

Identifiers

PMID37575192
PMCPMC10415929
OpenAlexW4384831836

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.