ArticleFrontiers in public health2023
Association between air pollution and primary liver cancer in European and east Asian populations: a Mendelian randomization study.
Article in Frontiers in public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global air pollution exposure and hepatocellular carcinoma: a systematic review and meta-analysis of epidemiological studies.BMC public health · 2025Pooled it
- Efficacy analysis of TACE in combination with anlotinib and sintilimab in the treatment of unresectable hepatocellular carcinoma.Scientific reports · 2025Trial
- Network-based toxicological analysis of core targets and pathways of bisphenol A-driven hepatocellular carcinoma.Biochemistry and biophysics reports · 2026Article
- Mendelian Randomization and Bioinformatics Analysis Reveal the Potential Protective Role of Metformin in Primary Liver Cancer.Food science & nutrition · 2025Article
- The Impact of Air Pollution on the Lung-Gut-Liver Axis: Oxidative Stress and Its Role in Liver Disease.Antioxidants (Basel, Switzerland) · 2025Review
- Correlation of air pollution and risk of sudden sensorineural hearing loss: a Mendelian randomization study.Scientific reports · 2025Article
- Global, regional and national burden of liver cancer 1990-2021: a systematic analysis of the global burden of disease study 2021.BMC public health · 2025Article
- Mendelian randomization analysis reveals causal relationship between depression, antidepressants and benign paroxysmal vertigo.Scientific reports · 2025Article
- Impact of Anthropogenic Factors on the Diversity of Microbial Communities of PM10 Air and PM100 ofBiology · 2024Article
- PMToxicology and applied pharmacology · 2024Article
- Causal relationship and shared genes between air pollutants and amyotrophic lateral sclerosis: A large-scale genetic analysis.CNS neuroscience & therapeutics · 2024Article
- Large-scale genome-wide association studies reveal the genetic causal etiology between air pollutants and autoimmune diseases.Journal of translational medicine · 2024Article
- Environmental PMeGastroenterology · 2024Article
- Exploring the link between walking and lung cancer risk: a two-stage Mendelian randomization analysis.BMC pulmonary medicine · 2024Article
- Nanotechnology for the Diagnosis and Treatment of Liver Cancer.International journal of nanomedicine · 2024Review
- Causal relationship between air pollution and infections: a two-sample Mendelian randomization study.Frontiers in public health · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The incidence of primary liver cancer is increasing year by year, with environmental factors playing a non-negligible role. At present, many studies are still disputing whether air pollution is associated with primary liver cancer incidence, and it is difficult to draw causal inferences. Therefore, in this study, we used two-sample Mendelian randomization (MR) to assess the causal relationship between air pollution (including PM2.5, PM2.5-10, PM10, nitrogen dioxide and nitrogen oxides) and primary liver cancer risk and its related biomarkers (Alpha-fetoprotein, Osteopontin, Glypican-3 and Arginase-1). Patients and methods: We used large-scale publicly available genome-wide association studies (GWAS) summary data to conduct MR analyses of European and East Asian populations. Inverse variance weighted (IVW) method was used as the main analysis method, and weighted median model, MR-Egger, simple model and weighted model methods were selected for quality control. Heterogeneity was checked by the Cochran's Q test. The MR-Egger regression and the MR-PRESSO global test detect pleiotropy. The sensitivity analysis was performed using the leave-one-out method. Results: Between air pollution and primary liver cancer in either European (PM2.5: Conclusion: This MR study found no evidence to support a causality between air pollution and primary liver cancer in European and East Asian populations, but nitrogen oxides may affect hepatocellular differentiation.
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