Evidence map›Paper›PMID 37574595›Full record

ArticleBrain and behavior2023

Longitudinal follow up of data-driven cognitive subtypes in Parkinson's disease.

Dana Pourzinal, Jihyun Yang, Kumareshan Sivakumaran, Katie L McMahon, Leander Mitchell, John D O'Sullivan, Gerard J Byrne, Nadeeka N Dissanayaka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dana PourzinalFaculty of Medicine, The University of Queensland Centre for Clinical Research, Herston, QLD, Australia.
Jihyun YangFaculty of Medicine, The University of Queensland Centre for Clinical Research, Herston, QLD, Australia.
Kumareshan SivakumaranFaculty of Medicine, The University of Queensland Centre for Clinical Research, Herston, QLD, Australia.
Katie L McMahonSchool of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.
Leander MitchellSchool of Psychology, The University of Queensland, St. Lucia, Australia.
John D O'SullivanFaculty of Medicine, The University of Queensland Centre for Clinical Research, Herston, QLD, Australia.
Gerard J ByrneFaculty of Medicine, The University of Queensland Centre for Clinical Research, Herston, QLD, Australia.
Nadeeka N DissanayakaFaculty of Medicine, The University of Queensland Centre for Clinical Research, Herston, QLD, Australia.ORCID 0000-0002-0164-3337
The University of Queensland · AUQueensland University of Technology · AU

Funding

Australian Association of GerontologyAustralian GovernmentNational Health and Medical Research Council
6 · The paper itself

Abstract

aimThe dual syndrome hypothesis proposes that there are two cognitive subtypes in Parkinson's disease (PD): a frontal subtype with executive/attention impairment and gradual cognitive decline, and a posterior-cortical subtype with memory/visuospatial deficits and rapid cognitive decline. We aimed to compare the rate of global cognitive decline between subtypes derived using data-driven methods and explore their longitudinal performance within specific cognitive domains to better understand the prognosis of each subtype.

methodFrontal, posterior-cortical, globally impaired, and cognitively intact PD subtypes were identified at baseline using k-means clustering (N = 85), and 29 participants (34%) returned for follow-up assessments on average 4.87 years from baseline. Linear mixed effects models compared progression of subtypes on global cognition; psychological symptoms; parkinsonism; and the memory, attention, executive, language, and visuospatial cognitive domains.

resultsThe frontal subtype was lost to attrition. While rate of change in parkinsonism, anxiety, and apathy differed between subtypes, there was no difference in the rate of global cognitive decline. However, the posterior-cortical subtype declined most rapidly in verbal memory, card sorting, trail making, and judgement of line orientation (JLO), while the cognitively intact group declined most rapidly on verbal memory and semantic fluency. The globally impaired subtype declined most rapidly in JLO, although this should be interpreted with caution due to high attrition.

conclusionDespite limited sample size, the present study supports the differential progression of the posterior-cortical subtype compared to cognitively intact and globally impaired PD. These results encourage further, large-scale longitudinal investigations of cognitive subtypes in PD.

Indexed as

CognitionCognitive DysfunctionParkinson DiseaseAgedAttentionDisease ProgressionExecutive FunctionFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological Testsclinical neuropsychologycognitive impairmentmild cognitive impairmentParkinson's disease

Identifiers

PMID37574595
PMCPMC10570472
OpenAlexW4385792700

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.